دورية أكاديمية
أعرض في EDS

Spectral domain optical coherence tomography findings in acute syphilitic posterior placoid chorioretinitis.

التفاصيل البيبلوغرافية
العنوان: Spectral domain optical coherence tomography findings in acute syphilitic posterior placoid chorioretinitis.
المؤلفون: Burkholder BM; The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 1800 Orleans St, Woods 476, Baltimore, MD 21287, USA. bryn@alumni.duke.edu., Leung TG, Ostheimer TA, Butler NJ, Thorne JE, Dunn JP
المصدر: Journal of ophthalmic inflammation and infection [J Ophthalmic Inflamm Infect] 2014 Jan 27; Vol. 4 (1), pp. 2. Date of Electronic Publication: 2014 Jan 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 101553216 Publication Model: Electronic Cited Medium: Print ISSN: 1869-5760 (Print) Linking ISSN: 18695760 NLM ISO Abbreviation: J Ophthalmic Inflamm Infect Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer
مستخلص: Background: We describe the spectral domain optical coherence tomography (SD-OCT) findings in three patients with acute syphilitic posterior placoid chorioretinitis (ASPPC). The SD-OCT images demonstrate the pathologic changes in ASPPC with a high level of anatomic detail and may provide information about the pathophysiology of the disease.
Findings: We report a series of three consecutive patients seen at the Wilmer Eye Institute in 2012 and 2013 who presented with clinical and laboratory findings consistent with a diagnosis of unilateral ASPPC. Two of the three patients had HIV co-infection with good immune recovery. SD-OCT images from their initial (pre-treatment) presentation demonstrated thickening and hyperreflective nodularity of the choroid-retinal pigment epithelium (RPE) complex, with focal disruption of the overlying photoreceptor inner segment-outer segment junction in the areas corresponding to the retinal lesions seen on clinical examination. These changes improved with intravenous antibiotic treatment over a 3-month period of follow-up.
Conclusions: SD-OCT imaging in ASPPC demonstrates reversible, focal thickening, and nodularity of the RPE with disruption of the overlying photoreceptor inner segment-outer segment junction. We believe that these SD-OCT images support the concept that ASPPC involves an inflammatory process at the level of the choroid-RPE with resultant structural and functional changes in the retinal photoreceptors. Further study with OCT imaging may be helpful in better understanding this disease.
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تواريخ الأحداث: Date Created: 20140129 Date Completed: 20140210 Latest Revision: 20220331
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC3917537
DOI: 10.1186/1869-5760-4-2
PMID: 24468306
قاعدة البيانات: MEDLINE
الوصف
تدمد:1869-5760
DOI:10.1186/1869-5760-4-2