دورية أكاديمية
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Vernonia condensata Baker (Asteraceae): a promising source of antioxidants.

التفاصيل البيبلوغرافية
العنوان: Vernonia condensata Baker (Asteraceae): a promising source of antioxidants.
المؤلفون: da Silva JB; Graduate Program in Pharmaceutical Sciences, Federal University of Juiz de Fora, Campus Universitário, 36036-330 Juiz de Fora, MG, Brazil ; Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, 36036-330 Juiz de Fora, MG, Brazil., Temponi Vdos S; Graduate Program in Pharmaceutical Sciences, Federal University of Juiz de Fora, Campus Universitário, 36036-330 Juiz de Fora, MG, Brazil ; Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, 36036-330 Juiz de Fora, MG, Brazil., Gasparetto CM; Graduate Program in Pharmaceutical Sciences, Federal University of Juiz de Fora, Campus Universitário, 36036-330 Juiz de Fora, MG, Brazil ; Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, 36036-330 Juiz de Fora, MG, Brazil., Fabri RL; Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, 36036-330 Juiz de Fora, MG, Brazil., Aragão DM; Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Campus Universitário, 36036-330 Juiz de Fora, MG, Brazil., Pinto Nde C; Graduate Program in Pharmaceutical Sciences, Federal University of Juiz de Fora, Campus Universitário, 36036-330 Juiz de Fora, MG, Brazil., Ribeiro A; Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Campus Universitário, 36036-330 Juiz de Fora, MG, Brazil., Scio E; Graduate Program in Pharmaceutical Sciences, Federal University of Juiz de Fora, Campus Universitário, 36036-330 Juiz de Fora, MG, Brazil ; Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Campus Universitário, 36036-330 Juiz de Fora, MG, Brazil., Del-Vechio-Vieira G; Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, 36036-330 Juiz de Fora, MG, Brazil., de Sousa OV; Graduate Program in Pharmaceutical Sciences, Federal University of Juiz de Fora, Campus Universitário, 36036-330 Juiz de Fora, MG, Brazil ; Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, 36036-330 Juiz de Fora, MG, Brazil., Alves MS; Graduate Program in Pharmaceutical Sciences, Federal University of Juiz de Fora, Campus Universitário, 36036-330 Juiz de Fora, MG, Brazil ; Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, 36036-330 Juiz de Fora, MG, Brazil.
المصدر: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2013; Vol. 2013, pp. 698018. Date of Electronic Publication: 2013 Dec 31.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101479826 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0994 (Electronic) Linking ISSN: 19420994 NLM ISO Abbreviation: Oxid Med Cell Longev Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011- : New York : Hindawi Pub. Corp.
Original Publication: 2008-2010: Austin, TX : Landes Bioscience
مواضيع طبية MeSH: Antioxidants/*analysis , Vernonia/*chemistry, Acetates/chemistry ; Apigenin/analysis ; Biphenyl Compounds/chemistry ; Chromatography, High Pressure Liquid ; Flavonoids/analysis ; Free Radical Scavengers/chemistry ; Luteolin/analysis ; Malondialdehyde/metabolism ; Molybdenum ; Oxidation-Reduction ; Phenols/analysis ; Phosphoric Acids ; Picrates/chemistry ; Plant Extracts/chemistry ; Spectrophotometry, Ultraviolet ; Thiobarbituric Acid Reactive Substances/metabolism
مستخلص: The present study evaluated the antioxidant potential of Vernonia condensata Baker (Asteraceae). Dried and powdered leaves were exhaustively extracted with ethanol by static maceration followed by partition to obtain the hexane, dichloromethane, ethyl acetate, and butanol fractions. Total phenols and flavonoids contents were determined through spectrophotometry and flavonoids were identified by HPLC-DAD system. The antioxidant activity was assessed by DPPH radical scavenging activity, TLC-bioautography, reducing power of Fe(+3), phosphomolybdenum, and TBA assays. The total phenolic content and total flavonoids ranged from 0.19 to 23.11 g/100 g and from 0.13 to 4.10 g/100 g, respectively. The flavonoids apigenin and luteolin were identified in the ethyl acetate fraction. The IC50 of DPPH assay varied from 4.28 to 75.10 µg/mL and TLC-bioautography detected the antioxidant compounds. The reducing power of Fe(+3) was 19.98 to 336.48  μg/mL, while the reaction with phosphomolybdenum ranged from 13.54% to 32.63% and 56.02% to 135.00% considering ascorbic acid and rutin as reference, respectively. At 30 mg/mL, the ethanolic extract and fractions revealed significant effect against lipid peroxidation. All these data sustain that V. condensata is an important and promising source of bioactive substances with antioxidant activity.
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المشرفين على المادة: 0 (Acetates)
0 (Antioxidants)
0 (Biphenyl Compounds)
0 (Flavonoids)
0 (Free Radical Scavengers)
0 (Phenols)
0 (Phosphoric Acids)
0 (Picrates)
0 (Plant Extracts)
0 (Thiobarbituric Acid Reactive Substances)
4Y8F71G49Q (Malondialdehyde)
76845O8NMZ (ethyl acetate)
7V515PI7F6 (Apigenin)
81AH48963U (Molybdenum)
DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
KUX1ZNC9J2 (Luteolin)
RN225F04V1 (phosphomolybdic acid)
تواريخ الأحداث: Date Created: 20140204 Date Completed: 20140715 Latest Revision: 20220330
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC3893806
DOI: 10.1155/2013/698018
PMID: 24489987
قاعدة البيانات: MEDLINE
الوصف
تدمد:1942-0994
DOI:10.1155/2013/698018