دورية أكاديمية
[Effect of orthodontic force on expression of Asporin after tooth auto-transplantation: an experimental study in Beagle dogs].
| العنوان: | [Effect of orthodontic force on expression of Asporin after tooth auto-transplantation: an experimental study in Beagle dogs]. |
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| المؤلفون: | Yue SC; Department of Orthodontics, Capital Medical University School of Stomatology, Beijing 100050, China., Bai YX; Department of Orthodontics, Capital Medical University School of Stomatology, Beijing 100050, China. Email: byuxing@263.net., Yang Y; Department of Orthodontics, Capital Medical University School of Stomatology, Beijing 100050, China., Li LX; Department of Orthodontics, Capital Medical University School of Stomatology, Beijing 100050, China. |
| المصدر: | Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology [Zhonghua Kou Qiang Yi Xue Za Zhi] 2013 Dec; Vol. 48 (12), pp. 745-9. |
| نوع المنشور: | English Abstract; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Chinese Medical Association Country of Publication: China NLM ID: 8711066 Publication Model: Print Cited Medium: Print ISSN: 1002-0098 (Print) Linking ISSN: 10020098 NLM ISO Abbreviation: Zhonghua Kou Qiang Yi Xue Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing : Chinese Medical Association Original Publication: Beijing : Zhonghua yi xue hui, 1987- |
| مواضيع طبية MeSH: | Orthodontic Extrusion*, Alkaline Phosphatase/*metabolism , Bone Morphogenetic Protein 2/*metabolism , Extracellular Matrix Proteins/*metabolism , Incisor/*transplantation, Alkaline Phosphatase/genetics ; Animals ; Bone Morphogenetic Protein 2/genetics ; Dogs ; Extracellular Matrix Proteins/genetics ; Incisor/metabolism ; Male ; Mandible ; Maxilla ; RNA, Messenger/metabolism ; Transplantation, Autologous |
| مستخلص: | Objective: To evaluate the effect of orthodontic light force on the expression of Asporin, bone morphogenetic proteins-2 (BMP-2) and alkaline phosphatase (ALP) after auto-transplantation. Methods: Thirty-two maxillary and mandibular incisors in four 13 month-old male Beagle dogs were auto-transplanted to the other side of the same jaw. The teeth were all endodontically treated and divided into four groups, control (group 1) and three experimental groups (groups 2, 3 and 4).In control group, the teeth were unloaded. In the other three experimental groups, continuous force was applied in the 1st week (group 2), 2nd week (group 3) and 4th week (group 4) after auto-transplantation, respectively. The dogs were sacrificed in the 8th week. The mRNA expressions of Asporin,BMP-2 and ALP were examined by real time PCR. The expression of periodontal ligament associated protein-1 (PLAP-1) was examined by Western blotting. The data were statistically analyzed using SPSS 17.0 and one-way analysis of variance (ANOVA). Results: In group 3, the expression of Asporin mRNA (2.047 ± 0.281) was higher than that in the other three groups, while the expression of BMP-2 (1.358 ± 0.095) was lower than that in group 2 and control group (P < 0.05). The expression of PLAP-1 (1.054 ± 0.113) in group 3 was higher than other groups, while significant difference was found between any two groups. Conclusions: Orthodontic force could stimulate the expression of Asporin and PLAP-1. The orthodontic force applied in the 2nd week after the tooth auto-transplantation, the expression of Asporin and PLAP-1 reached the highest level. |
| المشرفين على المادة: | 0 (Bone Morphogenetic Protein 2) 0 (Extracellular Matrix Proteins) 0 (RNA, Messenger) EC 3.1.3.1 (Alkaline Phosphatase) |
| تواريخ الأحداث: | Date Created: 20140206 Date Completed: 20140730 Latest Revision: 20140205 |
| رمز التحديث: | 20240628 |
| PMID: | 24495726 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1002-0098 |
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