دورية أكاديمية
أعرض في EDS

Bmp suppression in mangrove killifish embryos causes a split in the body axis.

التفاصيل البيبلوغرافية
العنوان: Bmp suppression in mangrove killifish embryos causes a split in the body axis.
المؤلفون: Mourabit S; Biosciences, College of Life & Environmental Sciences, University of Exeter, Exeter, United Kingdom., Moles MW; Biosciences, College of Life & Environmental Sciences, University of Exeter, Exeter, United Kingdom., Smith E; Biosciences, College of Life & Environmental Sciences, University of Exeter, Exeter, United Kingdom., van Aerle R; Biosciences, College of Life & Environmental Sciences, University of Exeter, Exeter, United Kingdom., Kudoh T; Biosciences, College of Life & Environmental Sciences, University of Exeter, Exeter, United Kingdom.
المصدر: PloS one [PLoS One] 2014 Jan 30; Vol. 9 (1), pp. e84786. Date of Electronic Publication: 2014 Jan 30 (Print Publication: 2014).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Bone Morphogenetic Proteins/*physiology , Fish Proteins/*physiology , Killifishes/*embryology, Animals ; Body Patterning/genetics ; Bone Morphogenetic Proteins/antagonists & inhibitors ; Embryo, Nonmammalian/metabolism ; Fish Proteins/antagonists & inhibitors ; Killifishes/metabolism ; Neural Tube/embryology ; Phenotype ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology ; Somites/embryology
مستخلص: Bone morphogenetic proteins (Bmp) are major players in the formation of the vertebrate body plan due to their crucial role in patterning of the dorsal-ventral (DV) axis. Despite the highly conserved nature of Bmp signalling in vertebrates, the consequences of changing this pathway can be species-specific. Here, we report that Bmp plays an important role in epiboly, yolk syncytial layer (YSL) movements, and anterior-posterior (AP) axis formation in embryos of the self-fertilizing mangrove killifish, Kryptolebias marmoratus. Stage and dose specific exposures of embryos to the Bmp inhibitor dorsomorphin (DM) produced three distinctive morphologies, with the most extreme condition creating the splitbody phenotype, characterised by an extremely short AP axis where the neural tube, somites, and notochord were bilaterally split. In addition, parts of caudal neural tissues were separated from the main body and formed cell islands in the posterior region of the embryo. This splitbody phenotype, which has not been reported in other animals, shows that modification of Bmp may lead to significantly different consequences during development in other vertebrate species.
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المشرفين على المادة: 0 (Bone Morphogenetic Proteins)
0 (Fish Proteins)
0 (Pyrazoles)
0 (Pyrimidines)
10K52CIC1Z (dorsomorphin)
تواريخ الأحداث: Date Created: 20140206 Date Completed: 20141222 Latest Revision: 20211021
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC3907431
DOI: 10.1371/journal.pone.0084786
PMID: 24497921
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0084786