دورية أكاديمية
Solution structure of a sponge-derived cystine knot peptide and its notable stability.
| العنوان: | Solution structure of a sponge-derived cystine knot peptide and its notable stability. |
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| المؤلفون: | Li H; College of Pharmacy, Pusan National University , Busan 609-735, Republic of Korea., Su M, Hamann MT, Bowling JJ, Kim HS, Jung JH |
| المصدر: | Journal of natural products [J Nat Prod] 2014 Feb 28; Vol. 77 (2), pp. 304-10. Date of Electronic Publication: 2014 Feb 05. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cincinnati, American Society of Pharmacognosy. |
| مواضيع طبية MeSH: | Cystine/*chemistry , Peptides/*chemistry , Porifera/*chemistry, Amino Acid Sequence ; Animals ; Chymotrypsin/metabolism ; Crystallography, X-Ray ; Humans ; Marine Biology ; Models, Molecular ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Pancreatic Elastase/metabolism ; Pepsin A/metabolism ; Protein Conformation ; Stereoisomerism ; Trypsin/metabolism |
| مستخلص: | A novel cystine knot peptide, asteropsin E (ASPE), was isolated from an Asteropus sp. marine sponge. The primary, secondary, and tertiary structures of ASPE were determined by high-resolution 2D NMR spectroscopy (900 MHz). With the exception of an N-terminal modification, ASPE shares properties with the previously reported asteropsins A-D, that is, the absence of basic residues, a highly acidic nature, conserved structurally important residues (including two cis-prolines), and a highly conserved tertiary structural framework. ASPE was found to be remarkably stable to gastrointestinal tract enzymes (chymotrypsin, elastase, pepsin, and trypsin) and to human plasma. |
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| معلومات مُعتمدة: | R01 AI036596 United States AI NIAID NIH HHS; R01 AT007318 United States AT NCCIH NIH HHS |
| سلسلة جزيئية: | PDB 2M3J |
| المشرفين على المادة: | 0 (Peptides) 0 (asteropsin E) 48TCX9A1VT (Cystine) EC 3.4.21.1 (Chymotrypsin) EC 3.4.21.36 (Pancreatic Elastase) EC 3.4.21.4 (Trypsin) EC 3.4.23.1 (Pepsin A) |
| تواريخ الأحداث: | Date Created: 20140207 Date Completed: 20140807 Latest Revision: 20211021 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC4128683 |
| DOI: | 10.1021/np400899a |
| PMID: | 24499386 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-6025 |
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| DOI: | 10.1021/np400899a |