دورية أكاديمية
Advanced digestive neuroendocrine tumors: metastatic pattern is an independent factor affecting clinical outcome.
| العنوان: | Advanced digestive neuroendocrine tumors: metastatic pattern is an independent factor affecting clinical outcome. |
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| المؤلفون: | Panzuto F; From the *Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, Rome; †Dept of Surgery, Pancreatic Surgery Unit, Università Politecnica delle Marche, Ancona; ‡Ospedale Sacro Cuore Don Calabria, Negrar; §Department of Clinical Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Bologna; ∥Radiology, ¶Pathology Unit, and #Surgery 1, Sapienza University of Rome, Sant'Andrea Hospital, Rome; **ARC-NET Center for Applied Research on Cancer and Department of Pathology and Diagnostics, University of Verona, Verona; and ††Medical Oncology, Università Politecnica delle Marche, Ancona, Italy., Merola E, Rinzivillo M, Partelli S, Campana D, Iannicelli E, Pilozzi E, Mercantini P, Rossi M, Capurso G, Scarpa A, Cascinu S, Tomassetti P, Falconi M, Delle Fave G |
| المصدر: | Pancreas [Pancreas] 2014 Mar; Vol. 43 (2), pp. 212-8. |
| نوع المنشور: | Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8608542 Publication Model: Print Cited Medium: Internet ISSN: 1536-4828 (Electronic) Linking ISSN: 08853177 NLM ISO Abbreviation: Pancreas Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: [New York, N.Y.] : Raven Press, [c1986- |
| مواضيع طبية MeSH: | Digestive System Neoplasms/*pathology , Liver Neoplasms/*secondary , Neuroendocrine Tumors/*pathology, Aged ; Digestive System Neoplasms/metabolism ; Digestive System Neoplasms/therapy ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Ki-67 Antigen/metabolism ; Liver Neoplasms/metabolism ; Liver Neoplasms/therapy ; Male ; Middle Aged ; Neoplasm Staging ; Neuroendocrine Tumors/metabolism ; Neuroendocrine Tumors/therapy ; Outcome Assessment, Health Care/statistics & numerical data ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors |
| مستخلص: | Objectives: The objective of this study was to determine the impact of different metastatic spread patterns on outcome in advanced digestive neuroendocrine tumors (NETs). Methods: This was a retrospective analysis of patients with stage IV NETs, classified as group 1 (unilobar liver metastases), group 2 (bilobar liver metastases), group 3 (extra-abdominal metastases). End points were overall survival (OS) and progression-free survival (PFS). Risk factor analysis was performed using Cox proportional hazard model. Results: Of the 229 patients, 135 (58.9%) had pancreatic, and 94 (41.1%) small bowel NETs: 32 (13.9%) were included in group 1, 179 (78.2%) in group 2, and 18 (7.9%) in group 3. Median Ki67 was 4.5%. Overall, 5-year OS was 55%. Different OS was observed among the 3 groups: median survival not reached, 81 and 8 months, respectively (P < 0.001). Median PFS was 18 months. Both OS and PFS were significantly affected by Ki67 and metastatic spread pattern. Conclusions: The stratification of stage IV NET patients based on metastatic patterns, alongside Ki67, predicts the clinical outcome. The extent of metastatic disease is a previously unrecognized variable, which should be considered when evaluating the results of treatments in NET patients with advanced disease. |
| المشرفين على المادة: | 0 (Ki-67 Antigen) |
| تواريخ الأحداث: | Date Created: 20140213 Date Completed: 20141020 Latest Revision: 20220331 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1097/MPA.0000000000000032 |
| PMID: | 24518498 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1536-4828 |
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| DOI: | 10.1097/MPA.0000000000000032 |