دورية أكاديمية
Efficacy of neoadjuvant chemotherapy in down staging locally advanced pre-menopausal breast cancer in Eastern Nigeria: is four courses adequate?
| العنوان: | Efficacy of neoadjuvant chemotherapy in down staging locally advanced pre-menopausal breast cancer in Eastern Nigeria: is four courses adequate? |
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| المؤلفون: | Egwuonwu OA; Department of Surgery, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria., Anyanwu SN, Nwofor AM |
| المصدر: | Journal of cancer research and therapeutics [J Cancer Res Ther] 2013 Oct-Dec; Vol. 9 (4), pp. 638-43. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medknow Publications Country of Publication: India NLM ID: 101249598 Publication Model: Print Cited Medium: Internet ISSN: 1998-4138 (Electronic) Linking ISSN: 19984138 NLM ISO Abbreviation: J Cancer Res Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Mumbai, India : Medknow Publications |
| مواضيع طبية MeSH: | Antibiotics, Antineoplastic/*therapeutic use , Antineoplastic Combined Chemotherapy Protocols/*therapeutic use , Breast Neoplasms/*drug therapy, Adult ; Chemotherapy, Adjuvant ; Cyclophosphamide/therapeutic use ; Doxorubicin/therapeutic use ; Female ; Fluorouracil/therapeutic use ; Humans ; Middle Aged ; Neoadjuvant Therapy ; Nigeria ; Premenopause ; Prognosis ; Prospective Studies ; Treatment Outcome |
| مستخلص: | Context: Breast cancer is the most frequent cancer among women in most part of the world and in Nigeria. Neoadjuvant chemotherapy (NAC) has been demonstrated to be a helpful strategy in the context of locally advanced breast cancer (LABC). Aims: To determine if the use of four courses of doxorubicin based neoadjuvant chemotherapeutic regimen will result in significant primary tumor down-staging. Settings and Design: One year prospective study of premenopausal breast cancer patients presenting to the specialty breast clinic. Methods: The patients were recommended for four courses of doxorubicin based NAC and response assessed using response evaluation criteria in solid tumors (RECIST) methodology. Statistical Analysis Used: Simple frequency and descriptive statistics were used to analyze data using SPSS statistical software. Results: One hundred and fourteen patients presented with breast cancer. Their ages ranged from 26 to 51 years with a mean age of 42.1 years ± 7.7 years. Thirty-one patients completed the four courses of NAC. At the end of NAC, 23 (74.2%) patients had more than 30% reduction in primary tumor size and 8 (25.8%) had no response (NR). The response according to the modified RECIST methodology was 12.9% for a complete clinical response, 61.3% for partial response, and 25.8% for NR. Significant clinical response was seen in 74.2% of patients (P < 0.0001) (one sample t-test). Conclusions: Four courses of antracycline based NAC is effective in premenopausal patients with LABC in our environment. |
| المشرفين على المادة: | 0 (Antibiotics, Antineoplastic) 80168379AG (Doxorubicin) 8N3DW7272P (Cyclophosphamide) U3P01618RT (Fluorouracil) |
| SCR Protocol: | CAF protocol |
| تواريخ الأحداث: | Date Created: 20140213 Date Completed: 20141204 Latest Revision: 20220316 |
| رمز التحديث: | 20231215 |
| DOI: | 10.4103/0973-1482.126463 |
| PMID: | 24518709 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1998-4138 |
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| DOI: | 10.4103/0973-1482.126463 |