دورية أكاديمية
The beneficial effects of rosuvastatin are independent of zinc supplementation in patients with atherosclerosis.
| العنوان: | The beneficial effects of rosuvastatin are independent of zinc supplementation in patients with atherosclerosis. |
|---|---|
| المؤلفون: | Dias PCS; Post Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil., Sena-Evangelista KCM; Department of Nutrition, Federal University of Rio Grande do Norte, Natal, RN, Brazil., Paiva MSMO; Onofre Lopes Hospital University, Federal University of Rio Grande do Norte, Natal, RN, Brazil., Ferreira DQC; Post Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil., Ururahy MAG; Post Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil., Rezende AA; Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Norte, Natal, RN, Brazil., Abdalla DSP; Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil., Pedrosa LFC; Department of Nutrition, Federal University of Rio Grande do Norte, Natal, RN, Brazil. Electronic address: lpedrosa@ufrnet.br. |
| المصدر: | Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2014 Apr; Vol. 28 (2), pp. 194-199. Date of Electronic Publication: 2014 Jan 29. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Gustav Fisher Country of Publication: Germany NLM ID: 9508274 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3252 (Electronic) Linking ISSN: 0946672X NLM ISO Abbreviation: J Trace Elem Med Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Stuttgart : Gustav Fisher Original Publication: Stuttgart ; New York : Gustav Fischer, c1995- |
| مواضيع طبية MeSH: | Dietary Supplements*, Atherosclerosis/*drug therapy , Fluorobenzenes/*therapeutic use , Pyrimidines/*therapeutic use , Sulfonamides/*therapeutic use , Zinc/*therapeutic use, Adult ; Aged ; Aged, 80 and over ; Anthropometry ; Biomarkers/metabolism ; Female ; Gene Expression Regulation ; Humans ; Male ; Metallothionein/genetics ; Metallothionein/metabolism ; Middle Aged ; Molecular Sequence Data ; Placebos ; Rosuvastatin Calcium |
| مستخلص: | Background: Statins have multiple antiatherosclerotic effects, but can reduce blood plasma concentrations of minerals, including zinc. As zinc possesses antiinflammatory and antioxidant effects, low zinc status can promote injuries or inadequate tissue repair in endothelial cells. Metallothionein (MT) expression might modulate responses induced by statins in patients with atherosclerosis. However, research regarding mineral status and the use of statins is scarce. This study evaluated the effects of zinc supplementation on zinc status and expression of the zinc-dependent MT1F and MT2A genes in patients with atherosclerosis treated with rosuvastatin. Methods: A double-blind, randomized clinical trial was performed with 54 participants treated with 10mg rosuvastatin for 4 months with or without zinc supplementation (30mg/day). Diet, lipid profile, high-sensitivity reactive protein C (hs-CRP), plasma and erythrocyte zinc concentrations, erythrocyte superoxide dismutase (SOD) activity, and MT1F and MT2A genes expression were analyzed before and after intervention. Results: Rosuvastatin therapy was effective in reducing low- and non-high-density lipoprotein, total cholesterol, triglycerides, and hs-CRP levels, independent of zinc supplementation. Additionally, zinc treatment had no effect on SOD enzyme activity (P=0.201), plasma (P>0.671) and erythrocyte (P>0.123) zinc concentrations, or the pattern of MT1F and MT2A genes expression (P=0.088 and P=0.229, respectively). Conclusions: The effectiveness of rosuvastatin treatment is independent of the effects of zinc supplementation. Moreover, rosuvastatin treatment did not have a significant impact on zinc status or MT1F and MT2A genes expression in patients with atherosclerosis. (Copyright © 2014 Elsevier GmbH. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Atherosclerosis; Metallothionein; Rosuvastatin; Zinc supplementation |
| سلسلة جزيئية: | GENBANK NM005949; NM005953 |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Fluorobenzenes) 0 (MT1F protein, human) 0 (MT2A protein, human) 0 (Placebos) 0 (Pyrimidines) 0 (Sulfonamides) 83MVU38M7Q (Rosuvastatin Calcium) 9038-94-2 (Metallothionein) J41CSQ7QDS (Zinc) |
| تواريخ الأحداث: | Date Created: 20140225 Date Completed: 20141203 Latest Revision: 20190831 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jtemb.2014.01.003 |
| PMID: | 24560278 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-3252 |
|---|---|
| DOI: | 10.1016/j.jtemb.2014.01.003 |