دورية أكاديمية
Studying the influence of hydrogel injections into the infarcted left ventricle using the element-free Galerkin method.
| العنوان: | Studying the influence of hydrogel injections into the infarcted left ventricle using the element-free Galerkin method. |
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| المؤلفون: | Legner D; Centre for Research in Computational and Applied Mechanics, University of Cape Town, Cape Town, South Africa; Computational Continuum Mechanics Group, Department of Civil Engineering, University of Cape Town, Cape Town, South Africa., Skatulla S, MBewu J, Rama RR, Reddy BD, Sansour C, Davies NH, Franz T |
| المصدر: | International journal for numerical methods in biomedical engineering [Int J Numer Method Biomed Eng] 2014 Mar; Vol. 30 (3), pp. 416-29. Date of Electronic Publication: 2013 Dec 26. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 101530293 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2040-7947 (Electronic) Linking ISSN: 20407939 NLM ISO Abbreviation: Int J Numer Method Biomed Eng Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Oxford, UK] : Wiley |
| مواضيع طبية MeSH: | Computer Simulation* , Models, Cardiovascular*, Heart Ventricles/*physiopathology , Hydrogel, Polyethylene Glycol Dimethacrylate/*therapeutic use , Myocardial Infarction/*physiopathology , Myocardial Infarction/*therapy, Biomechanical Phenomena ; Humans ; Stress, Mechanical |
| مستخلص: | Myocardial infarction is an increasing health problem worldwide. Because of an under-supply of blood, the cardiomyocytes in the affected region permanently lose their ability to contract. This in turn gradually weakens the overall heart function. A new therapeutic approach based on the injection of a gel into the infarcted area aims to support the healing and to inhibit adverse remodelling that can lead to heart failure. A computational model is the basis for obtaining a better understanding of the heart mechanics, in particular, how myocardial infarction and gel injections affect its pumping performance. A strain invariant-based stored energy function is proposed to account for the passive mechanical behaviour of the model, which also makes provision for active contraction. To incorporate injections an additive homogenization approach is introduced. The numerical framework is developed using an in-house code based on the element-free Galerkin method. The main focus of this contribution is to investigate the influence of gel injections on the mechanics of the left ventricle during the diastolic filling and systolic isovolumetric (isochoric) contraction phases. It is found that gel injections are able to reduce the elevated fibre stresses caused by an infarct. (Copyright © 2013 John Wiley & Sons, Ltd.) |
| فهرسة مساهمة: | Keywords: computational cardiology; injection therapy; meshless method; myocardial infarction |
| المشرفين على المادة: | 25852-47-5 (Hydrogel, Polyethylene Glycol Dimethacrylate) |
| تواريخ الأحداث: | Date Created: 20140228 Date Completed: 20141021 Latest Revision: 20171116 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1002/cnm.2610 |
| PMID: | 24574184 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2040-7947 |
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| DOI: | 10.1002/cnm.2610 |