دورية أكاديمية
أعرض في EDS

Potent anti-inflammatory activity of pyrenocine A isolated from the marine-derived fungus Penicillium paxilli Ma(G)K.

التفاصيل البيبلوغرافية
العنوان: Potent anti-inflammatory activity of pyrenocine A isolated from the marine-derived fungus Penicillium paxilli Ma(G)K.
المؤلفون: Toledo TR; Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista 'Júlio de Mesquita Filho', 14801-902 Araraquara, SP, Brazil., Dejani NN; Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista 'Júlio de Mesquita Filho', 14801-902 Araraquara, SP, Brazil ; Faculdade de Medicina Ribeirão Preto, Universidade de São Paulo, 14049-900 Ribeirão Preto, SP, Brazil., Monnazzi LG; Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista 'Júlio de Mesquita Filho', 14801-902 Araraquara, SP, Brazil., Kossuga MH; Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, 13560-970 São Carlos, SP, Brazil., Berlinck RG; Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, 13560-970 São Carlos, SP, Brazil., Sette LD; Departamento de Bioquímica e Microbiologia, Instituto de Biociências, Universidade Estadual Paulista 'Júlio de Mesquita Filho', 13506-900 Rio Claro, SP, Brazil., Medeiros AI; Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista 'Júlio de Mesquita Filho', 14801-902 Araraquara, SP, Brazil.
المصدر: Mediators of inflammation [Mediators Inflamm] 2014; Vol. 2014, pp. 767061. Date of Electronic Publication: 2014 Jan 19.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 9209001 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1466-1861 (Electronic) Linking ISSN: 09629351 NLM ISO Abbreviation: Mediators Inflamm Subsets: MEDLINE
أسماء مطبوعة: Publication: 2005- : Sylvania, OH : Hindawi Pub. Corp.
Original Publication: Oxford, UK : Rapid Communications of Oxford Ltd., c1992-
مواضيع طبية MeSH: Anti-Inflammatory Agents/*pharmacology , Dinoprostone/*metabolism , Lipopolysaccharides/*chemistry , Penicillium/*chemistry, Animals ; Anti-Inflammatory Agents/chemistry ; Cell Adhesion ; Cell Line ; Cell Membrane/metabolism ; CpG Islands ; Cytokines/metabolism ; Gene Expression Profiling ; Gene Expression Regulation ; Immunosuppressive Agents/chemistry ; Inflammation ; Lymphocyte Activation ; Macrophage Activation ; Macrophages/cytology ; Macrophages/drug effects ; Macrophages/metabolism ; Mice ; Myeloid Differentiation Factor 88/metabolism ; Nitrites/chemistry ; Pyrones/chemistry ; Pyrones/pharmacology ; Signal Transduction
مستخلص: Very little is known about the immunomodulatory potential of secondary metabolites isolated from marine microorganisms. In the present study, we characterized pyrenocine A, which is produced by the marine-derived fungus Penicillium paxilli Ma(G)K and possesses anti-inflammatory activity. Pyrenocine A was able to suppress, both pretreatment and posttreatment, the LPS-induced activation of macrophages via the inhibition of nitrite production and the synthesis of inflammatory cytokines and PGE2. Pyrenocine A also exhibited anti-inflammatory effects on the expression of receptors directly related to cell migration (Mac-1) as well as costimulatory molecules involved in lymphocyte activation (B7.1). Nitrite production was inhibited by pyrenocine A in macrophages stimulated with CpG but not Poly I:C, suggesting that pyrenocine A acts through the MyD88-dependent intracellular signaling pathway. Moreover, pyrenocine A is also able to inhibit the expression of genes related to NF κ B-mediated signal transduction on macrophages stimulated by LPS. Our results indicate that pyrenocine A has promissory anti-inflammatory properties and additional experiments are necessary to confirm this finding in vivo model.
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المشرفين على المادة: 0 (Anti-Inflammatory Agents)
0 (Cytokines)
0 (Immunosuppressive Agents)
0 (Lipopolysaccharides)
0 (Myd88 protein, mouse)
0 (Myeloid Differentiation Factor 88)
0 (Nitrites)
0 (Pyrones)
76868-97-8 (pyrenocine A)
K7Q1JQR04M (Dinoprostone)
تواريخ الأحداث: Date Created: 20140228 Date Completed: 20141016 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3916108
DOI: 10.1155/2014/767061
PMID: 24574582
قاعدة البيانات: MEDLINE
الوصف
تدمد:1466-1861
DOI:10.1155/2014/767061