دورية أكاديمية
The determination of acrylamide in environmental and drinking waters by large-volume injection - hydrophilic-interaction liquid chromatography and tandem mass spectrometry.
| العنوان: | The determination of acrylamide in environmental and drinking waters by large-volume injection - hydrophilic-interaction liquid chromatography and tandem mass spectrometry. |
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| المؤلفون: | Backe WJ; Public Health Laboratory Division , Minnesota Department of Health, 601 Robert Street North, P.O. Box 64899, Saint Paul, MN 55164-0899, USA. Electronic address: will.backe@state.mn.us., Yingling V; Environmental Health Division, Minnesota Department of Health, 625 Robert Street North, P.O. Box 64975, Saint Paul, MN 55164-0975, USA., Johnson T; Environmental Health Division, Minnesota Department of Health, 705 5th Street NW, Bemidji, MN 56601-2933, USA. |
| المصدر: | Journal of chromatography. A [J Chromatogr A] 2014 Mar 21; Vol. 1334, pp. 72-8. Date of Electronic Publication: 2014 Feb 08. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Validation Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3778 (Electronic) Linking ISSN: 00219673 NLM ISO Abbreviation: J Chromatogr A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier, 1993- |
| مواضيع طبية MeSH: | Acrylamide/*analysis , Chromatography, Liquid/*methods , Drinking Water/*chemistry , Tandem Mass Spectrometry/*methods , Water Pollutants, Chemical/*analysis, Atmospheric Pressure ; Hydrophobic and Hydrophilic Interactions ; Limit of Detection ; Mining ; Rivers/chemistry |
| مستخلص: | A simple and sensitive analytical method was developed to quantify levels of acrylamide in environmental and drinking waters. The analytical method consisted of solvent exchanging acrylamide from 2mL of water into 2mL of dichloromethane using acetonitrile as an intermediate. The sample was then directly analyzed by large-volume (750μL) injection - hydrophilic-interaction liquid chromatography and tandem mass spectrometry. The method detection limit and reporting level were 2.4ng/L and 17ng/L of acrylamide, respectively. The recovery of acrylamide during solvent exchange was 95±2.8% and the matrix effects were 12±2.2% in river water. The use of atmospheric-pressure chemical ionization reduced matrix effects; however, it also reduced method sensitivity by a factor of 2.2 compared to electrospray ionization. Matrix effects were compensated for by the use of an isotopically-labeled internal standard and the method accuracy was 89±3.0% at 25ng/L of acrylamide and 102±2.6% at 250ng/L of acrylamide. The precision of the method was less than 6% relative standard deviation at both 25ng/L and 250ng/L of acrylamide. Samples from a sand-and-gravel mine and a drinking-water treatment plant were acquired to demonstrate the method. The concentrations of acrylamide at the sand-and-gravel mine were up to 280ng/L. In the drinking-water treatment plant, the concentration of acrylamide was approximately double in the finished drinking water when compared to other stages in the drinking-water treatment process. Disinfection or fluoridation may result in higher concentrations of acrylamide in finished drinking water; however, further research in this area is necessary. (Copyright © 2014 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Acrylamide; Drinking-water treatment; HILIC; HPLC–MS/MS; Hydrophilic-interaction liquid chromatography; Large-volume injection |
| المشرفين على المادة: | 0 (Drinking Water) 0 (Water Pollutants, Chemical) 20R035KLCI (Acrylamide) |
| تواريخ الأحداث: | Date Created: 20140304 Date Completed: 20140725 Latest Revision: 20191210 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.chroma.2014.02.005 |
| PMID: | 24582391 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3778 |
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| DOI: | 10.1016/j.chroma.2014.02.005 |