دورية أكاديمية
أعرض في EDS

SCGB2A1 is a novel prognostic marker for colorectal cancer associated with chemoresistance and radioresistance.

التفاصيل البيبلوغرافية
العنوان: SCGB2A1 is a novel prognostic marker for colorectal cancer associated with chemoresistance and radioresistance.
المؤلفون: Munakata K; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Japan., Uemura M; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Japan., Takemasa I; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Japan., Ozaki M; Department of Frontier Science for Cancer and Chemotherapy, Graduate School of Medicine, Osaka University, Japan., Konno M; Department of Frontier Science for Cancer and Chemotherapy, Graduate School of Medicine, Osaka University, Japan., Nishimura J; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Japan., Hata T; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Japan., Mizushima T; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Japan., Haraguchi N; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Japan., Noura S; Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan., Ikenaga M; Department of Surgery, Osaka Rosai Hospital, Japan., Okamura S; Department of Surgery, Suita Municipal Hospital, Japan., Fukunaga M; Department of Surgery, Sakai City Hospital, Japan., Murata K; Department of Surgery, Suita Municipal Hospital, Japan., Yamamoto H; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Japan., Doki Y; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Japan., Mori M; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Japan.
المصدر: International journal of oncology [Int J Oncol] 2014 May; Vol. 44 (5), pp. 1521-8. Date of Electronic Publication: 2014 Feb 28.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9306042 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-2423 (Electronic) Linking ISSN: 10196439 NLM ISO Abbreviation: Int J Oncol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2003->: Athens, Greece : D.A. Spandidos
Original Publication: Athens, Greece : Lychnia,
مواضيع طبية MeSH: Colorectal Neoplasms/*genetics , Colorectal Neoplasms/*pathology , Mammaglobin B/*genetics , Mammaglobin B/*metabolism, Aged ; Analysis of Variance ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Colorectal Neoplasms/diagnosis ; Drug Resistance, Neoplasm ; Female ; Fluorouracil/pharmacology ; Gene Expression Regulation, Neoplastic ; Homeodomain Proteins/genetics ; Humans ; Male ; Middle Aged ; Organoplatinum Compounds/pharmacology ; Oxaliplatin ; Radiation Tolerance ; Transcription Factors/genetics ; Twist-Related Protein 1/genetics ; Wnt Proteins/genetics ; Zinc Finger E-box-Binding Homeobox 1
مستخلص: We recently showed that liver metastatic tissue from patients with colorectal cancer (CRC) was a useful model for identifying novel, hypoxia-inducible genes and prognostic markers. We showed that the expression of secretoglobin, family 2A, member 1 (SCGB2A1) was a potential prognostic factor for CRC. Here, we further evaluated the prognostic impact and function of SCGB2A1 in 222 patients with CRC. The impact of SCGB2A1 expression on disease-free survival (DFS) and overall survival (OS) was assessed with mRNA expression profiling. The function of SCGB2A1 was analyzed by evaluating mRNA expression profiles in cells derived from patients with CRC and by testing the effects of transfecting SCGB2A1 into different CRC-derived cell lines. We evaluated the effects of SCGB2A1 on proliferation, chemosensitivity, radiation sensitivity and sphere formation. Univariate and multivariate analyses indicated that the expression of SCGB2A1 was an independent prognostic factor for CRC (p<0.05), together with lymph node metastasis (p<0.05). Enforced expression of SCGB2A1 in CRC-derived cell lines promoted proliferation (DLD1, SW480 and LoVo cells; p<0.05), decreased chemosensitivity to 5-fluorouracil and oxaliplatin (DLD1 and SW480 cell lines; p<0.05), and significantly increased the viability of irradiated cells (DLD1, SW480 and LoVo cell lines; p<0.05). SCGB2A1 expression was also correlated to cancer stemness-related genes (Wnt, Zeb1 and Twist). Consistent with this correlation, SCGB2A1 expressing cells (SW480) showed increased sphere formation (p<0.05). These results indicated that SCGB2A1 represented a novel, prognostic factor for CRC, and that expression of SCGB2A1 correlated with chemoresistance, radioresistance and cancer cell stemness.
المشرفين على المادة: 0 (Antineoplastic Agents)
0 (Homeodomain Proteins)
0 (Mammaglobin B)
0 (Organoplatinum Compounds)
0 (SCGB2A1 protein, human)
0 (Transcription Factors)
0 (Twist-Related Protein 1)
0 (Wnt Proteins)
0 (ZEB1 protein, human)
0 (Zinc Finger E-box-Binding Homeobox 1)
04ZR38536J (Oxaliplatin)
U3P01618RT (Fluorouracil)
تواريخ الأحداث: Date Created: 20140304 Date Completed: 20141113 Latest Revision: 20181202
رمز التحديث: 20221213
DOI: 10.3892/ijo.2014.2316
PMID: 24585249
قاعدة البيانات: MEDLINE
الوصف
تدمد:1791-2423
DOI:10.3892/ijo.2014.2316