دورية أكاديمية
[Sentinel lymph node in pulmonary carcinoma. Molecular study after radioisotope detection].
| العنوان: | [Sentinel lymph node in pulmonary carcinoma. Molecular study after radioisotope detection]. |
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| عنوان ترانسليتريتد: | El ganglio centinela en el carcinoma pulmonar. Estudio molecular tras detección con radioisótopo. |
| المؤلفون: | Galbis Caravajal JM, Mira AC, Cabrera ÁZ, Guerrero ME, Ferrairó AT, Martinez Hernandez NJ, Sarrió RG, Aparisi FA, Martinez CG |
| المصدر: | Cirugia espanola [Cir Esp] 2014 Jan; Vol. 92 (1), pp. 11-5. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | Spanish; Castilian |
| بيانات الدورية: | Publisher: Elsevier España Country of Publication: Spain NLM ID: 1254104 Publication Model: Print Cited Medium: Internet ISSN: 1578-147X (Electronic) Linking ISSN: 0009739X NLM ISO Abbreviation: Cir Esp Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Madrid : Elsevier España Original Publication: Madrid, Paz Montalvo. |
| مواضيع طبية MeSH: | Radiopharmaceuticals* , Technetium Tc 99m Aggregated Albumin*, Lung Neoplasms/*diagnostic imaging , Lung Neoplasms/*pathology , Sentinel Lymph Node Biopsy/*methods, Aged ; Female ; Humans ; Lung Neoplasms/genetics ; Male ; Middle Aged ; Molecular Diagnostic Techniques ; Radionuclide Imaging |
| مستخلص: | Introduction: Metastatic lymph node affectation is the main prognostic factor in localized lung cancer. Pathological study of the obtained samples even after an adequate lymphadenectomy, present tumoral relapses of 40% of stage I patients after oncological curative surgery. In this paper we have studied micrometastasis in the sentinel lymph node by molecular methods in patients with stage I lung cancer. Material and Methods: The sentinel node was marked by injecting peritumorally performed just after performing the thoracotomy with 2 mCi of nanocoloid of albumin (Nanocol®) marked with 99mTc in 0.3 ml. Guided with a Navigator® gammagraphic sensor, we proceeded to its resection. RNA of the tissue was extracted and the presence of genes CEACAM5, PLUNC and CK7 in mRNA was studied. Results: Twenty nine 29 patients were included. Of the tested genes, CEACAM5 and PLUNC were the ones that showed a high expression in lung tissue. Of the 29 analyzed sentinel lymph nodes, 7 (24%) were positive in the molecular study. A positive sentinel lymph node was found in 4/7 adenocarcinomas and 3/12 squamous-cell tumors. Affected lymph nodes were: station 5 (1/3), station 7 (0/6), station 9 (0/1); station 10 (5/11); station 11 (1/1). Conclusions: Detection of sentinel node in patients with stage I lung cancer by marking with radioisotope is a feasible technique. The application of molecular techniques shows the tumoral affectation in cases staged as stage I. |
| المشرفين على المادة: | 0 (Radiopharmaceuticals) 0 (Technetium Tc 99m Aggregated Albumin) 0 (technetium Tc 99m nanocolloid) |
| تواريخ الأحداث: | Date Created: 20140304 Date Completed: 20150406 Latest Revision: 20171130 |
| رمز التحديث: | 20221213 |
| PMID: | 24588016 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1578-147X |
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