دورية أكاديمية
أعرض في EDS

Eosinophilic oesophagitis: clinical presentation and pathogenesis.

التفاصيل البيبلوغرافية
العنوان: Eosinophilic oesophagitis: clinical presentation and pathogenesis.
المؤلفون: Bystrom J; Bone and Joint Research Unit, William Harvey Research Institute, Barts & the London, Queen Mary University of London, , London, UK., O'Shea NR
المصدر: Postgraduate medical journal [Postgrad Med J] 2014 May; Vol. 90 (1063), pp. 282-9. Date of Electronic Publication: 2014 Mar 19.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0234135 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-0756 (Electronic) Linking ISSN: 00325473 NLM ISO Abbreviation: Postgrad Med J Subsets: MEDLINE
أسماء مطبوعة: Publication: 2023- : Oxford : Oxford University Press
Original Publication: London, Blackwell.
مواضيع طبية MeSH: Adrenal Cortex Hormones/*administration & dosage , Anti-Inflammatory Agents/*administration & dosage , Eosinophilic Esophagitis/*diagnosis , Esophagus/*pathology, Adult ; Constriction, Pathologic/diagnosis ; Constriction, Pathologic/therapy ; Deglutition Disorders/etiology ; Dilatation/methods ; Eosinophilic Esophagitis/complications ; Eosinophilic Esophagitis/pathology ; Eosinophilic Esophagitis/physiopathology ; Eosinophilic Esophagitis/therapy ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Treatment Outcome
مستخلص: Eosinophilic oesophagitis (EoE) is an inflammatory disorder of the oesophagus which has become increasingly recognised over recent years, although it remains underdiagnosed in many centres. It is characterised histologically by a significant eosinophilic infiltration of the oesophageal mucosa (>15 eosinophils per high powered field), and clinically with features of oesophageal dysfunction such a dysphagia, food impaction, and proton pump inhibitor (PPI) resistant dyspepsia. Fibrosis and oesophageal remodelling may occur and lead to oesophageal strictures. An allergic predisposition is common in the EoE population, which appears to be primarily food antigen driven in children and aeroallergen driven in adults. Evidence suggests that the pathogenesis of EoE is due to a dysregulated immunological response to an environmental allergen, resulting in a T helper type 2 (Th2) inflammatory disease and remodelling of the oesophagus in genetically susceptible individuals. Allergen elimination and anti-inflammatory therapy with corticosteroids are currently the mainstay of treatment; however, an increasing number of studies are now focused on targeting different stages in the disease pathogenesis. A greater understanding of the underlying mechanisms resulting in EoE will allow us to improve the therapeutic options available.
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فهرسة مساهمة: Keywords: HISTOPATHOLOGY; IMMUNOLOGY; PUBLIC HEALTH
المشرفين على المادة: 0 (Adrenal Cortex Hormones)
0 (Anti-Inflammatory Agents)
تواريخ الأحداث: Date Created: 20140321 Date Completed: 20150119 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4495666
DOI: 10.1136/postgradmedj-2012-131403
PMID: 24647582
قاعدة البيانات: MEDLINE
الوصف
تدمد:1469-0756
DOI:10.1136/postgradmedj-2012-131403