دورية أكاديمية
Laboratory investigation of epidemic dropsy in Addis Ababa, Ethiopia.
| العنوان: | Laboratory investigation of epidemic dropsy in Addis Ababa, Ethiopia. |
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| المؤلفون: | Assefa A, Teka F, Guta M, Melaku D, Naser E, Tesfaye B, Messele T, Kebede A, Getachew M, Mudi K, Alebachew A, Azazh A, Bane A, Seboxa T, Girma S, Muzein R, Urga K |
| المصدر: | Ethiopian medical journal [Ethiop Med J] 2013 Oct; Vol. Suppl 2, pp. 21-32. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Ethiopian Medical Association Country of Publication: Ethiopia NLM ID: 0373223 Publication Model: Print Cited Medium: Print ISSN: 0014-1755 (Print) Linking ISSN: 00141755 NLM ISO Abbreviation: Ethiop Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Addis Ababa : Ethiopian Medical Association |
| مواضيع طبية MeSH: | Disease Outbreaks* , Food Contamination*, Cardiotonic Agents/*adverse effects , Edema/*epidemiology , Edema/*therapy , Plant Oils/*adverse effects, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Benzophenanthridines/adverse effects ; Benzophenanthridines/toxicity ; Cardiotonic Agents/toxicity ; Child ; Diet Surveys ; Edema/diagnosis ; Ethiopia/epidemiology ; Female ; Humans ; Isoquinolines/adverse effects ; Isoquinolines/toxicity ; Lower Extremity ; Male ; Mice ; Middle Aged ; Plant Oils/toxicity ; Risk Factors ; Toxicity Tests ; Young Adult |
| مستخلص: | Background: Food adulteration including adulteration of edible oils may cause serious health problems. One of the most common edible adulterants is argemone oil. An outbreak of epidemic dropsy occurred in Addis Ababa during May-June, 2008. One hundred and eighty two cases were recorded with twelve confirmed deaths. Dietary history of the cases revealed that vegetable oils were the usual cooking medium. Objective: The aim of the study was hence to investigate the causes of this outbreak. Methods: Contaminant identification was done using standard chemical tests, complemented with TLC. Toxicity study was done using Swiss albino mice feed with contaminated and non contaminated standard diet for 30 days. Results: Laboratory investigation of the edible oils has indicated that 47 of the 280 edible oils analyzed were adulterated with argemone oil. About 81% of the edible oil samples collected from Lideta sub-city were adulterated with argemone oil. Toxicological investigation of the adulterated oils also indicated typical features of argemone alkaloid poisoning in mice. Conclusion: Results of both laboratory analysis and toxicological studies confirmed consumption of edible oils adulterated with argemone oil as the cause of epidemic dropsy in Addis Ababa. |
| المشرفين على المادة: | 0 (Benzophenanthridines) 0 (Cardiotonic Agents) 0 (Isoquinolines) 0 (Plant Oils) 0 (argemone oil) AV9VK043SS (sanguinarine) |
| تواريخ الأحداث: | Date Created: 20140325 Date Completed: 20140424 Latest Revision: 20140324 |
| رمز التحديث: | 20221213 |
| PMID: | 24654506 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0014-1755 |
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