دورية أكاديمية
Effects of ALDH2∗2 on alcohol problem trajectories of Asian American college students.
| العنوان: | Effects of ALDH2∗2 on alcohol problem trajectories of Asian American college students. |
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| المؤلفون: | Luczak SE; Department of Psychology, University of Southern California., Yarnell LM; Department of Psychology, University of Southern California., Prescott CA; Department of Psychology, University of Southern California., Myers MG; Department of Psychology, University of California., Liang T; Department of Medicine, Indiana University., Wall TL; Department of Psychology, University of California. |
| المصدر: | Journal of abnormal psychology [J Abnorm Psychol] 2014 Feb; Vol. 123 (1), pp. 130-40. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Psychological Association Country of Publication: United States NLM ID: 0034461 Publication Model: Print Cited Medium: Internet ISSN: 1939-1846 (Electronic) Linking ISSN: 0021843X NLM ISO Abbreviation: J Abnorm Psychol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington Dc : American Psychological Association |
| مواضيع طبية MeSH: | Alcohol Drinking/*genetics , Alcoholism/*genetics , Aldehyde Dehydrogenase/*genetics , Asian/*genetics, Adolescent ; Adolescent Behavior/psychology ; Alcohol Drinking/psychology ; Alcoholism/psychology ; Aldehyde Dehydrogenase, Mitochondrial ; Alleles ; Environment ; Female ; Gene-Environment Interaction ; Genotype ; Humans ; Longitudinal Studies ; Male ; Students ; Universities ; Young Adult |
| مستخلص: | The variant aldehyde dehydrogenase allele, ALDH2∗2, consistently has been associated with protection against alcohol dependence, but the mechanism underlying this process is not known. This study examined growth trajectories of alcohol consumption (frequency, average quantity, binge drinking, maximum drinks) and problems over the college years and then tested whether the ALDH2 genotype mediated or moderated the relationship between alcohol consumption and problems. Asian American college students (N = 433) reported on their drinking behavior in their first year of college and then annually for 3 consecutive years. Alcohol consumption and problems increased over the college years for both those with and without ALDH2∗2, but having an ALDH2∗2 allele was associated with less of an increase in problems over time. A mediation model was supported, with ALDH2∗2 group differences in problems fully accounted for by differences in frequency of binge drinking. Findings also supported a moderation hypothesis: All four alcohol consumption variables were significant predictors of subsequent alcohol problems, but these relationships were not as strong in those with ALDH2∗2 as in those without ALDH2∗2. Our findings suggest that the interplay between ALDH2∗2 and drinking-related problems is complex, involving both mediation and moderation processes that reduce the likelihood of developing problems via reduction of heavy drinking as well as by altering the relationship between alcohol consumption and problems. Results of this longitudinal study provide evidence that what seems like a relatively straightforward effect of a diminished ability to metabolize alcohol on drinking behavior is actually dependent on behavior and developmental stage. (PsycINFO Database Record (c) 2014 APA, all rights reserved.) |
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| معلومات مُعتمدة: | K02 DA017652 United States DA NIDA NIH HHS; K08 AA014265 United States AA NIAAA NIH HHS; K02 AA00269 United States AA NIAAA NIH HHS; K08 AA14265 United States AA NIAAA NIH HHS; R01 AA18179 United States AA NIAAA NIH HHS; R01 AA11257 United States AA NIAAA NIH HHS; R01 AA018179 United States AA NIAAA NIH HHS; R01 AA011257 United States AA NIAAA NIH HHS; K02 AA000269 United States AA NIAAA NIH HHS |
| المشرفين على المادة: | EC 1.2.1.3 (ALDH2 protein, human) EC 1.2.1.3 (Aldehyde Dehydrogenase) EC 1.2.1.3 (Aldehyde Dehydrogenase, Mitochondrial) |
| تواريخ الأحداث: | Date Created: 20140326 Date Completed: 20150413 Latest Revision: 20221207 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC4074595 |
| DOI: | 10.1037/a0035486 |
| PMID: | 24661165 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1939-1846 |
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| DOI: | 10.1037/a0035486 |