دورية أكاديمية
Induced and spontaneous heart rate turbulence in mice: influence of coupling interval.
| العنوان: | Induced and spontaneous heart rate turbulence in mice: influence of coupling interval. |
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| المؤلفون: | Stöckigt F; Department of Medicine-Cardiology, University Hospital Bonn, Sigmund Freud Str. 25, 53127Bonn, Germany florian.stoeckigt@ukb.uni-bonn.de., Pöhlmann S; Department of Medicine-Cardiology, University Hospital Bonn, Sigmund Freud Str. 25, 53127Bonn, Germany., Nickenig G; Department of Medicine-Cardiology, University Hospital Bonn, Sigmund Freud Str. 25, 53127Bonn, Germany., Schwab JO; Department of Medicine-Cardiology, University Hospital Bonn, Sigmund Freud Str. 25, 53127Bonn, Germany., Schrickel JW; Department of Medicine-Cardiology, University Hospital Bonn, Sigmund Freud Str. 25, 53127Bonn, Germany. |
| المصدر: | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology [Europace] 2014 Jul; Vol. 16 (7), pp. 1092-8. Date of Electronic Publication: 2014 Mar 26. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 100883649 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2092 (Electronic) Linking ISSN: 10995129 NLM ISO Abbreviation: Europace Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2006- : Oxford : Oxford University Press Original Publication: London ; Philadelphia : Saunders, c1999- |
| مواضيع طبية MeSH: | Heart Rate*, Arrhythmias, Cardiac/*physiopathology , Cardiac Pacing, Artificial/*methods, Algorithms ; Animals ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/etiology ; Baroreflex ; Blood Pressure ; Disease Models, Animal ; Electrocardiography ; Electrophysiologic Techniques, Cardiac ; Feasibility Studies ; Mice, Inbred C57BL ; Predictive Value of Tests ; Signal Processing, Computer-Assisted ; Telemetry ; Time Factors ; Ventricular Premature Complexes/diagnosis ; Ventricular Premature Complexes/etiology ; Ventricular Premature Complexes/physiopathology |
| مستخلص: | Aims: Heart rate turbulence (HRT) is a prognostic parameter for risk stratification in patients suffering from coronary artery disease. The aims of this study were to demonstrate the feasibility of quantifying HRT in mice, both in long-term electrocardiograms (ECGs) as well as after extrastimulus pacing, and to analyse its characteristics. Methods and Results: We performed long-term ECG recordings using implanted telemetric chips and electrophysiological (EP) investigations, using transvenously inserted EP catheters, in healthy mice. Heart rate turbulence was calculated using the established turbulence onset (TO) and slope (TS) algorithm. After spontaneous ventricular premature complexes (VPCs), we found a negative TO (-2.2 ± 7.5%) and positive TS (15.5 ± 18.3 ms/RR interval). Electrophysiological investigations revealed positive values for TO (0.6 ± 1.1%) and TS (6.5 ± 2.9 ms/RR interval) after extrastimulus pacing maneuvers. The shortening of the extrastimuli coupling intervals delivered during EP investigations significantly influenced TO (r = 0.57; P = 0.01): shorter coupling intervals provoked more positive TO values. Conclusion: Mice display both spontaneous and induced HRT. In terms of TO, VPCs generated by extrastimulus pacing are significantly dependent on the coupling interval. Determining HRT in mice is feasible and provides insight into basic mechanisms of blood pressure regulation, which is realized by the baroreflex. (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: Baroreflex; Electrophysiological investigation; Heart rate turbulence; Long-term ECG recording; Mice |
| تواريخ الأحداث: | Date Created: 20140328 Date Completed: 20150219 Latest Revision: 20140626 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1093/europace/eut357 |
| PMID: | 24671168 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1532-2092 |
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| DOI: | 10.1093/europace/eut357 |