دورية أكاديمية
Degraded speech sound processing in a rat model of fragile X syndrome.
العنوان: | Degraded speech sound processing in a rat model of fragile X syndrome. |
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المؤلفون: | Engineer CT; School of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road GR41, Richardson, TX 75080, United States. Electronic address: novitski@utdallas.edu., Centanni TM; School of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road GR41, Richardson, TX 75080, United States., Im KW; School of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road GR41, Richardson, TX 75080, United States., Rahebi KC; School of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road GR41, Richardson, TX 75080, United States., Buell EP; School of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road GR41, Richardson, TX 75080, United States., Kilgard MP; School of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road GR41, Richardson, TX 75080, United States. |
المصدر: | Brain research [Brain Res] 2014 May 20; Vol. 1564, pp. 72-84. Date of Electronic Publication: 2014 Apr 05. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Amsterdam Elsevier/North-Holland Biomedical Press. |
مواضيع طبية MeSH: | Auditory Cortex/*physiopathology , Auditory Perception/*physiology , Discrimination, Psychological/*physiology , Fragile X Mental Retardation Protein/*genetics , Fragile X Syndrome/*physiopathology , Neurons/*physiology, Animals ; Disease Models, Animal ; Gene Knockout Techniques ; Male ; Phonetics ; Rats |
مستخلص: | Fragile X syndrome is the most common inherited form of intellectual disability and the leading genetic cause of autism. Impaired phonological processing in fragile X syndrome interferes with the development of language skills. Although auditory cortex responses are known to be abnormal in fragile X syndrome, it is not clear how these differences impact speech sound processing. This study provides the first evidence that the cortical representation of speech sounds is impaired in Fmr1 knockout rats, despite normal speech discrimination behavior. Evoked potentials and spiking activity in response to speech sounds, noise burst trains, and tones were significantly degraded in primary auditory cortex, anterior auditory field and the ventral auditory field. Neurometric analysis of speech evoked activity using a pattern classifier confirmed that activity in these fields contains significantly less information about speech sound identity in Fmr1 knockout rats compared to control rats. Responses were normal in the posterior auditory field, which is associated with sound localization. The greatest impairment was observed in the ventral auditory field, which is related to emotional regulation. Dysfunction in the ventral auditory field may contribute to poor emotional regulation in fragile X syndrome and may help explain the observation that later auditory evoked responses are more disturbed in fragile X syndrome compared to earlier responses. Rodent models of fragile X syndrome are likely to prove useful for understanding the biological basis of fragile X syndrome and for testing candidate therapies. (Copyright © 2014 Elsevier B.V. All rights reserved.) |
References: | J Neurosci. 2010 Aug 4;30(31):10263-71. (PMID: 20685971) Am J Med Genet. 1991 Feb-Mar;38(2-3):493-7. (PMID: 2018092) Eur J Neurosci. 2007 May;25(9):2819-34. (PMID: 17459110) PLoS One. 2013 Oct 16;8(10):e78607. (PMID: 24147140) Neuroscience. 2010 Apr 14;166(4):1140-57. (PMID: 20105453) Int J Psychophysiol. 2004 Aug;53(3):161-9. (PMID: 15246670) Dev Neurosci. 2011;33(5):395-403. (PMID: 22067669) Neuron. 2012 Apr 12;74(1):49-56. (PMID: 22500629) Am J Psychiatry. 2004 Nov;161(11):2117-20. (PMID: 15514415) Cereb Cortex. 2004 Jul;14(7):768-80. (PMID: 15084491) Brain Res. 2007 Oct 12;1174:76-91. (PMID: 17854780) Am J Med Genet. 1999 Apr 2;83(4):268-79. (PMID: 10208160) Ann Neurol. 2008 Jan;63(1):40-51. (PMID: 17932962) J Neurophysiol. 2005 Nov;94(5):3590-600. (PMID: 16093336) Nat Commun. 2013;4:2585. (PMID: 24121634) J Neurodev Disord. 2011 Dec;3(4):335-47. (PMID: 21993552) Neuroscience. 2013 Aug 29;246:186-98. (PMID: 23660195) Eur J Neurosci. 2011 Dec;34(11):1823-38. (PMID: 22098331) J Neurosci. 2010 Nov 17;30(46):15616-27. (PMID: 21084617) J Neurophysiol. 2012 Mar;107(5):1457-75. (PMID: 22131375) J Neurosci. 2013 Dec 11;33(50):19715-23. (PMID: 24336735) J Neurosci. 1994 May;14(5 Pt 1):2606-23. (PMID: 8182430) Neuron. 2007 Dec 20;56(6):955-62. (PMID: 18093519) J Neurosci. 2011 Oct 5;31(40):14223-34. (PMID: 21976507) Neurology. 1994 Jul;44(7):1317-24. (PMID: 8035938) Nat Neurosci. 2008 May;11(5):609-16. (PMID: 18408717) Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):E505-14. (PMID: 22308358) Ann N Y Acad Sci. 2012 Apr;1252:325-31. (PMID: 22524375) Brain Topogr. 2003 Spring;15(3):165-71. (PMID: 12705812) Mol Psychiatry. 2004 Apr;9(4):417-25. (PMID: 14981523) Psychoneuroendocrinology. 2002 Oct;27(7):855-72. (PMID: 12183220) Dev Neurorehabil. 2013;16(1):58-66. (PMID: 23249372) Behav Brain Res. 2011 May 16;219(1):68-74. (PMID: 21167211) Neuroreport. 2006 Nov 27;17(17):1761-6. (PMID: 17164660) Brain Res. 2013 Apr 19;1506:12-24. (PMID: 23458504) Front Evol Neurosci. 2012 Aug 16;4:12. (PMID: 22912615) Pediatrics. 2009 Jan;123(1):378-90. (PMID: 19117905) J Comp Neurol. 2012 Jan 1;520(1):34-51. (PMID: 21618239) J Neurophysiol. 2007 May;97(5):3621-38. (PMID: 17376842) Clin Neurophysiol. 2012 Jul;123(7):1309-18. (PMID: 22192499) Dev Neurobiol. 2014 Oct;74(10):972-86. (PMID: 24639033) Front Neural Circuits. 2008 Oct 29;2:4. (PMID: 18989389) J Cogn Neurosci. 2005 May;17(5):819-31. (PMID: 15904548) Behav Brain Res. 2014 Jan 1;258:166-78. (PMID: 24344364) Neuron. 2008 Aug 28;59(4):634-47. (PMID: 18760699) Nat Neurosci. 2008 May;11(5):603-8. (PMID: 18425123) J Neurophysiol. 2007 Jul;98(1):253-65. (PMID: 17460101) J Speech Lang Hear Res. 2009 Aug;52(4):1048-61. (PMID: 19641081) Neuroscience. 2003;119(1):9-13. (PMID: 12763063) J Neurosci. 2009 Jan 28;29(4):1034-45. (PMID: 19176812) J Pediatr Psychol. 2013 Apr;38(3):276-84. (PMID: 23143607) J Speech Lang Hear Res. 2005 Apr;48(2):494-500. (PMID: 15989407) Cogn Syst Res. 2008 Oct;9(4):274-292. (PMID: 19802322) Neuron. 2001 Apr;30(1):275-87. (PMID: 11343661) Nat Neurosci. 2010 Nov;13(11):1428-32. (PMID: 20890293) Cereb Cortex. 2013 Mar;23(3):670-83. (PMID: 22426334) Trends Neurosci. 2004 Jul;27(7):370-7. (PMID: 15219735) Neuron. 2011 Apr 14;70(1):121-31. (PMID: 21482361) Nat Neurosci. 2013 Jul;16(7):903-9. (PMID: 23727819) AJNR Am J Neuroradiol. 2010 Jan;31(1):131-9. (PMID: 19749222) J Comp Neurol. 2010 May 15;518(10):1630-46. (PMID: 20232478) Hear Res. 1999 Aug;134(1-2):16-28. (PMID: 10452372) Cereb Cortex. 2015 Jan;25(1):271-9. (PMID: 23968838) Neuron. 2010 Feb 11;65(3):385-98. (PMID: 20159451) Brain Lang. 2013 Jan;124(1):96-116. (PMID: 23295209) J Neurosci. 2013 Oct 2;33(40):15686-92. (PMID: 24089476) Cereb Cortex. 2008 Dec;18(12):2941-51. (PMID: 18424777) Neural Plast. 2011;2011:921680. (PMID: 21826280) Neuroscience. 2013 Nov 12;252:80-97. (PMID: 23954862) Neuroreport. 2001 Aug 8;12(11):2573-6. (PMID: 11496151) Cogn Neuropsychol. 2004 Sep 1;21(6):579-96. (PMID: 21038223) Cereb Cortex. 2014 Jul;24(7):1753-66. (PMID: 23395846) J Neurosci. 2014 Jan 8;34(2):446-50. (PMID: 24403144) Biol Psychiatry. 1987 Mar;22(3):303-12. (PMID: 2949781) Biol Psychiatry. 2014 Feb 1;75(3):189-97. (PMID: 23910948) J Intellect Disabil Res. 2011 Jan;55(1):19-29. (PMID: 21121991) Neuroscience. 2012 Mar 15;205:81-90. (PMID: 22249158) Radiology. 2011 Aug;260(2):521-30. (PMID: 21628495) J Assoc Res Otolaryngol. 2012 Aug;13(4):527-42. (PMID: 22549175) Front Hum Neurosci. 2012 Sep 24;6:264. (PMID: 23015788) J Neurophysiol. 2013 Jul;110(1):177-89. (PMID: 23596332) Neuron. 2007 May 24;54(4):627-38. (PMID: 17521574) Clin Neurophysiol. 2012 Apr;123(4):720-9. (PMID: 21958658) Annu Rev Neurosci. 1999;22:567-631. (PMID: 10202549) JAMA Psychiatry. 2013 Nov;70(11):1215-23. (PMID: 24068330) J Autism Dev Disord. 2009 Aug;39(8):1185-96. (PMID: 19353261) Neuroscience. 2014 Jan 31;258:292-306. (PMID: 24286757) Am J Med Genet A. 2013 Nov;161A(11):2809-21. (PMID: 24115651) |
معلومات مُعتمدة: | R01 DC010433 United States DC NIDCD NIH HHS; 5R01DC010433 United States DC NIDCD NIH HHS |
فهرسة مساهمة: | Keywords: Auditory cortex; Fragile X syndrome; Speech |
المشرفين على المادة: | 0 (Fmr1 protein, rat) 139135-51-6 (Fragile X Mental Retardation Protein) |
تواريخ الأحداث: | Date Created: 20140410 Date Completed: 20141209 Latest Revision: 20211021 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC4034469 |
DOI: | 10.1016/j.brainres.2014.03.049 |
PMID: | 24713347 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1872-6240 |
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DOI: | 10.1016/j.brainres.2014.03.049 |