دورية أكاديمية
Evaluation of oxidative stress using exhaled breath 8-isoprostane levels on chronic kidney disease.
| العنوان: | Evaluation of oxidative stress using exhaled breath 8-isoprostane levels on chronic kidney disease. |
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| المؤلفون: | Tiryaki BS, Tasliyurt T; Department of Internal Medicine, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey., Yelken BM, Sahin S, Kutluturk F, Koseoglu HI, Ozturk B, Yilmaz A, Sahin S |
| المصدر: | Nigerian journal of clinical practice [Niger J Clin Pract] 2014 May-Jun; Vol. 17 (3), pp. 356-60. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medknow Publications Country of Publication: India NLM ID: 101150032 Publication Model: Print Cited Medium: Print ISSN: 1119-3077 (Print) NLM ISO Abbreviation: Niger J Clin Pract Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Mumbai : Medknow Publications Original Publication: [Lagos?] : Medical and Dental Consultants' Association of Nigeria |
| مواضيع طبية MeSH: | Breath Tests/*methods , Dinoprost/*analogs & derivatives , Oxidative Stress/*physiology , Renal Insufficiency, Chronic/*metabolism, Adult ; Aged ; Dinoprost/metabolism ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies |
| مستخلص: | Background: There have been limited numbers of studies on patients with chronic kidney disease (CKD) to determine oxidative stress in exhaled breath condensate (EBC). Those two studies have been carried out on hemodialysis patients, and hydrogen peroxide and nitric oxide have been studied in order to show oxidative stress on EBC. Aims: We investigated oxidative stress in EBC evaluating 8-isoprostane levels on different stages of CKD. Materials and Methods: A total of 81 patients with 2-4 CKD stages have been evaluated prospectively. The patients have been categorized into three groups according to their CKD stages. For biochemical analysis, blood and breathing air samples were taken. 8-isoprostane has been measured using immunoassay method as the indicator of oxidative stress in EBC. Results: 8-isoprostane values were 8.19 ± 4.56, 13.89 ± 8.70, and 14.20 ± 10.68 pg/min group 1, 2, and 3, respectively; and the EBC 8-isoprostane levels increased significantly as CKD stages advanced (P0 = 0.018). There was a statistically significant reverse correlation between 8-isoprostane and glomerular filtration rate (GFR; r = -0.275; P = 0.014), but not between 8-isoprostane and C-reactive protein (r = -0.183; P = 0.177). Conclusions: We determined the level of 8-isoprostane in EBC of patients with different stages of CKD and showed that the level of 8-isoprostane significantly increased through the progress of CKD. We consider that our study is important because there have been limited number of studies that evaluate oxidative stress in CKD using EBC which is a noninvasive method. |
| المشرفين على المادة: | 27415-26-5 (8-epi-prostaglandin F2alpha) B7IN85G1HY (Dinoprost) |
| تواريخ الأحداث: | Date Created: 20140410 Date Completed: 20140625 Latest Revision: 20140731 |
| رمز التحديث: | 20221213 |
| DOI: | 10.4103/1119-3077.130240 |
| PMID: | 24714017 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1119-3077 |
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| DOI: | 10.4103/1119-3077.130240 |