دورية أكاديمية
أعرض في EDS

Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1.

التفاصيل البيبلوغرافية
العنوان: Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1.
المؤلفون: Richards J; Department of Medicine, University of Florida, USA; Department of Biochemistry and Molecular Biology, University of Florida, USA., Welch AK; Department of Medicine, University of Florida, USA; North Florida/South Georgia Veterans Health System, Gainesville, FL, USA., Barilovits SJ; Department of Medicine, University of Florida, USA; Department of Biochemistry and Molecular Biology, University of Florida, USA., All S; Department of Medicine, University of Florida, USA., Cheng KY; Department of Medicine, University of Florida, USA., Wingo CS; Department of Medicine, University of Florida, USA; North Florida/South Georgia Veterans Health System, Gainesville, FL, USA., Cain BD; Department of Biochemistry and Molecular Biology, University of Florida, USA., Gumz ML; Department of Medicine, University of Florida, USA; Department of Biochemistry and Molecular Biology, University of Florida, USA. Electronic address: Michelle.Gumz@medicine.ufl.edu.
المصدر: Life sciences [Life Sci] 2014 Nov 24; Vol. 118 (2), pp. 255-62. Date of Electronic Publication: 2014 Apr 08.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: <2008->: Amsterdam : Elsevier
Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press.
مواضيع طبية MeSH: Circadian Clocks*/genetics , Organ Specificity*/genetics, Endothelins/*metabolism , Period Circadian Proteins/*metabolism, Animals ; Endothelin-1/metabolism ; Gene Expression Profiling ; Gene Expression Regulation ; Kidney/metabolism ; Mice ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptor, Endothelin A/metabolism ; Receptor, Endothelin B/metabolism ; Time Factors
مستخلص: Aims: The present study is designed to consider a role for the circadian clock protein Per1 in the regulation of the endothelin axis in mouse kidney, lung, liver and heart. Renal endothelin-1 (ET-1) is a regulator of the epithelial sodium channel (ENaC) and blood pressure (BP), via activation of both endothelin receptors, ETA and ETB. However, ET-1 mediates many complex events in other tissues.
Main Methods: Tissues were collected in the middle of murine rest and active phases, at noon and midnight, respectively. ET-1, ETA and ETB mRNA expressions were measured in the lung, heart, liver, renal inner medulla and renal cortex of wild type and Per1 heterozygous mice using real-time quantitative RT-PCR.
Key Findings: The effect of reduced Per1 expression on levels of mRNAs and the time-dependent regulation of expression of the endothelin axis genes appeared to be tissue-specific. In the renal inner medulla and the liver, ETA and ETB exhibited peaks of expression in opposite circadian phases. In contrast, expressions of ET-1, ETA and ETB in the lung did not appear to vary with time, but ET-1 expression was dramatically decreased in this tissue in Per1 heterozygous mice. Interestingly, ET-1 and ETA, but not ETB, were expressed in a time-dependent manner in the heart.
Significance: Per1 appears to regulate expression of the endothelin axis genes in a tissue-specific and time-dependent manner. These observations have important implications for our understanding of the best time of day to deliver endothelin receptor antagonists.
(Copyright © 2014. Published by Elsevier Inc.)
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معلومات مُعتمدة: DK085193 United States DK NIDDK NIH HHS; K01 DK085193 United States DK NIDDK NIH HHS; L30 DK096643 United States DK NIDDK NIH HHS; T32 HL083810 United States HL NHLBI NIH HHS; T32 DK007518 United States DK NIDDK NIH HHS; 2T32HL083810 United States HL NHLBI NIH HHS; DK082680 United States DK NIDDK NIH HHS; R01 DK082680 United States DK NIDDK NIH HHS; L30 TR001247 United States TR NCATS NIH HHS; R03 DK098460 United States DK NIDDK NIH HHS; DK098460 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: ETA; ETB; Endothelin-A receptor; Endothelin-B receptor; Gene regulation
المشرفين على المادة: 0 (Endothelin-1)
0 (Endothelins)
0 (Per1 protein, mouse)
0 (Period Circadian Proteins)
0 (RNA, Messenger)
0 (Receptor, Endothelin A)
0 (Receptor, Endothelin B)
تواريخ الأحداث: Date Created: 20140412 Date Completed: 20150930 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4387882
DOI: 10.1016/j.lfs.2014.03.028
PMID: 24721511
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0631
DOI:10.1016/j.lfs.2014.03.028