دورية أكاديمية
Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1.
العنوان: | Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1. |
---|---|
المؤلفون: | Richards J; Department of Medicine, University of Florida, USA; Department of Biochemistry and Molecular Biology, University of Florida, USA., Welch AK; Department of Medicine, University of Florida, USA; North Florida/South Georgia Veterans Health System, Gainesville, FL, USA., Barilovits SJ; Department of Medicine, University of Florida, USA; Department of Biochemistry and Molecular Biology, University of Florida, USA., All S; Department of Medicine, University of Florida, USA., Cheng KY; Department of Medicine, University of Florida, USA., Wingo CS; Department of Medicine, University of Florida, USA; North Florida/South Georgia Veterans Health System, Gainesville, FL, USA., Cain BD; Department of Biochemistry and Molecular Biology, University of Florida, USA., Gumz ML; Department of Medicine, University of Florida, USA; Department of Biochemistry and Molecular Biology, University of Florida, USA. Electronic address: Michelle.Gumz@medicine.ufl.edu. |
المصدر: | Life sciences [Life Sci] 2014 Nov 24; Vol. 118 (2), pp. 255-62. Date of Electronic Publication: 2014 Apr 08. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2008->: Amsterdam : Elsevier Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press. |
مواضيع طبية MeSH: | Circadian Clocks*/genetics , Organ Specificity*/genetics, Endothelins/*metabolism , Period Circadian Proteins/*metabolism, Animals ; Endothelin-1/metabolism ; Gene Expression Profiling ; Gene Expression Regulation ; Kidney/metabolism ; Mice ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptor, Endothelin A/metabolism ; Receptor, Endothelin B/metabolism ; Time Factors |
مستخلص: | Aims: The present study is designed to consider a role for the circadian clock protein Per1 in the regulation of the endothelin axis in mouse kidney, lung, liver and heart. Renal endothelin-1 (ET-1) is a regulator of the epithelial sodium channel (ENaC) and blood pressure (BP), via activation of both endothelin receptors, ETA and ETB. However, ET-1 mediates many complex events in other tissues. Main Methods: Tissues were collected in the middle of murine rest and active phases, at noon and midnight, respectively. ET-1, ETA and ETB mRNA expressions were measured in the lung, heart, liver, renal inner medulla and renal cortex of wild type and Per1 heterozygous mice using real-time quantitative RT-PCR. Key Findings: The effect of reduced Per1 expression on levels of mRNAs and the time-dependent regulation of expression of the endothelin axis genes appeared to be tissue-specific. In the renal inner medulla and the liver, ETA and ETB exhibited peaks of expression in opposite circadian phases. In contrast, expressions of ET-1, ETA and ETB in the lung did not appear to vary with time, but ET-1 expression was dramatically decreased in this tissue in Per1 heterozygous mice. Interestingly, ET-1 and ETA, but not ETB, were expressed in a time-dependent manner in the heart. Significance: Per1 appears to regulate expression of the endothelin axis genes in a tissue-specific and time-dependent manner. These observations have important implications for our understanding of the best time of day to deliver endothelin receptor antagonists. (Copyright © 2014. Published by Elsevier Inc.) |
References: | Br J Pharmacol. 2013 Jan;168(2):327-34. (PMID: 22220553) Hypertension. 2012 Jun;59(6):1151-6. (PMID: 22526258) Annu Rev Physiol. 2010;72:517-49. (PMID: 20148687) Neuron. 2001 May;30(2):525-36. (PMID: 11395012) J Biol Chem. 2010 Sep 10;285(37):28520-8. (PMID: 20647310) Am J Physiol Renal Physiol. 2006 Jun;290(6):F1315-9. (PMID: 16380457) Circulation. 2000 Jan 18;101(2):142-7. (PMID: 10637200) Am J Physiol Regul Integr Comp Physiol. 2013 Oct 1;305(7):R735-47. (PMID: 23824961) Br J Pharmacol. 2005 Jan;144(1):115-22. (PMID: 15644875) N Engl J Med. 1993 Jun 17;328(24):1732-9. (PMID: 8497283) Am J Physiol Regul Integr Comp Physiol. 2010 Feb;298(2):R254-60. (PMID: 19907001) Front Physiol. 2013 Feb 19;4:22. (PMID: 23424003) Am J Physiol Renal Physiol. 2008 Oct;295(4):F1063-70. (PMID: 18667482) Curr Opin Genet Dev. 2003 Jun;13(3):271-7. (PMID: 12787789) Am J Physiol Regul Integr Comp Physiol. 2013 Jun 15;304(12):R1053-64. (PMID: 23576606) Circ Res. 1996 Feb;78(2):302-11. (PMID: 8575074) Am J Physiol. 1992 Apr;262(4 Pt 1):E412-6. (PMID: 1373562) J Clin Invest. 1990 Mar;85(3):653-8. (PMID: 2155922) Dig Dis Sci. 2013 Sep;58(9):2542-9. (PMID: 23625292) Am J Physiol Cell Physiol. 2012 Jan 1;302(1):C188-94. (PMID: 21918182) J Pharm Pharmacol. 2011 Nov;63(11):1373-7. (PMID: 21988418) Life Sci. 2012 Oct 15;91(13-14):490-500. (PMID: 22480517) FASEB J. 2012 Sep;26(9):3602-13. (PMID: 22661008) Gastroenterology. 1996 Feb;110(2):534-48. (PMID: 8566602) Am J Physiol Regul Integr Comp Physiol. 2013 Oct 1;305(7):R659-68. (PMID: 23986358) J Mol Cell Cardiol. 2013 Sep;62:189-202. (PMID: 23756157) Am J Physiol Renal Physiol. 2013 Aug 15;305(4):F568-73. (PMID: 23698114) FASEB J. 2011 Jan;25(1):16-28. (PMID: 20837776) Clin Sci (Lond). 2013 Dec;125(11):521-32. (PMID: 23642207) J Am Soc Nephrol. 2011 Apr;22(4):598-604. (PMID: 21436284) J Clin Invest. 2013 May;123(5):1902-10. (PMID: 23635788) Am J Physiol Heart Circ Physiol. 2001 Aug;281(2):H596-605. (PMID: 11454562) Mol Cell Biol. 2003 Nov;23(22):8226-32. (PMID: 14585980) Eur Respir Rev. 2013 Sep 1;22(129):217-26. (PMID: 23997048) Am J Physiol Renal Physiol. 2006 Dec;291(6):F1274-80. (PMID: 16868309) N Engl J Med. 2013 Aug 29;369(9):809-18. (PMID: 23984728) Life Sci. 2012 Oct 15;91(13-14):517-21. (PMID: 22884806) Ann Intern Med. 1991 Mar 15;114(6):464-9. (PMID: 1994793) Methods. 2001 Dec;25(4):402-8. (PMID: 11846609) Am J Physiol Renal Physiol. 2008 Dec;295(6):F1635-40. (PMID: 18784261) Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G948-57. (PMID: 22301113) Physiol Rev. 2011 Jan;91(1):1-77. (PMID: 21248162) J Biol Chem. 2009 Oct 30;284(44):30087-96. (PMID: 19638349) Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9266-70. (PMID: 8415690) J Pharmacol Exp Ther. 2013 Aug;346(2):182-9. (PMID: 23709116) Hepatology. 1998 Feb;27(2):472-80. (PMID: 9462646) |
معلومات مُعتمدة: | DK085193 United States DK NIDDK NIH HHS; K01 DK085193 United States DK NIDDK NIH HHS; L30 DK096643 United States DK NIDDK NIH HHS; T32 HL083810 United States HL NHLBI NIH HHS; T32 DK007518 United States DK NIDDK NIH HHS; 2T32HL083810 United States HL NHLBI NIH HHS; DK082680 United States DK NIDDK NIH HHS; R01 DK082680 United States DK NIDDK NIH HHS; L30 TR001247 United States TR NCATS NIH HHS; R03 DK098460 United States DK NIDDK NIH HHS; DK098460 United States DK NIDDK NIH HHS |
فهرسة مساهمة: | Keywords: ETA; ETB; Endothelin-A receptor; Endothelin-B receptor; Gene regulation |
المشرفين على المادة: | 0 (Endothelin-1) 0 (Endothelins) 0 (Per1 protein, mouse) 0 (Period Circadian Proteins) 0 (RNA, Messenger) 0 (Receptor, Endothelin A) 0 (Receptor, Endothelin B) |
تواريخ الأحداث: | Date Created: 20140412 Date Completed: 20150930 Latest Revision: 20211021 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC4387882 |
DOI: | 10.1016/j.lfs.2014.03.028 |
PMID: | 24721511 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1879-0631 |
---|---|
DOI: | 10.1016/j.lfs.2014.03.028 |