دورية أكاديمية
Allometric scaling of marbofloxacin pharmacokinetics: a retrospective analysis.
| العنوان: | Allometric scaling of marbofloxacin pharmacokinetics: a retrospective analysis. |
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| المؤلفون: | Yohannes S, Hossain MA, Kim JY, Lee SJ, Kwak DM, Suh JW, Park SC |
| المصدر: | Polish journal of veterinary sciences [Pol J Vet Sci] 2014; Vol. 17 (1), pp. 99-103. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Polish Academy of Sciences. Committee of Veterinary Sciences Country of Publication: Germany NLM ID: 101125473 Publication Model: Print Cited Medium: Print ISSN: 1505-1773 (Print) Linking ISSN: 15051773 NLM ISO Abbreviation: Pol J Vet Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2016- > : [Olsztyn] : Polish Academy of Sciences. Committee of Veterinary Sciences ; University of Warmia and Mazury Original Publication: Olsztyn, Poland : HARD Pub. Co., [1998- |
| مواضيع طبية MeSH: | Body Weight*, Anti-Bacterial Agents/*pharmacokinetics , Fluoroquinolones/*pharmacokinetics, Animals ; Half-Life ; Retrospective Studies ; Species Specificity ; Tissue Distribution |
| مستخلص: | The association between physiologically dependent pharmacokinetic parameters (CL(B), T1/2beta, Vd(ss)) of marbofloxacin and body weight was studied in eight animal species based on allometric equation Y = aWb, where 'Y' is the pharmacokinetic parameter, 'W' is body weight, 'a' is allometric coefficient (intercept) and 'b' is the exponent that describes relation between pharmacokinetic parameter and body weight. The body clearance of marbofloxacin has shown significant (P < 0.0001) relation with size (Bwt) in various animal species. However, half-life and volume of distribution were not in association with body weight. Although half-life and volume of distribution were not in a good correlation with body weight, statistically significant association between the body clearance and body weight suggests validity of allometric scaling for predicting pharmacokinetic parameters of marbofloxacin in animal species that have not been studied yet. However further study considering large sample size and other parameters influencing pharmacokinetics of marbofloxacin is recommended. |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Fluoroquinolones) 8X09WU898T (marbofloxacin) |
| تواريخ الأحداث: | Date Created: 20140415 Date Completed: 20140516 Latest Revision: 20191112 |
| رمز التحديث: | 20221213 |
| DOI: | 10.2478/pjvs-2014-0013 |
| PMID: | 24724476 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1505-1773 |
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| DOI: | 10.2478/pjvs-2014-0013 |