دورية أكاديمية
Impact of the blood sampling site on time-concentration drug profiles following intravenous or buccal drug administration.
| العنوان: | Impact of the blood sampling site on time-concentration drug profiles following intravenous or buccal drug administration. |
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| المؤلفون: | Hedges AR, Pypendop BH, Shilo Y, Stanley SD, Ilkiw JE |
| المصدر: | Journal of veterinary pharmacology and therapeutics [J Vet Pharmacol Ther] 2014 Apr; Vol. 37 (2), pp. 145-50. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 7910920 Publication Model: Print Cited Medium: Internet ISSN: 1365-2885 (Electronic) Linking ISSN: 01407783 NLM ISO Abbreviation: J Vet Pharmacol Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, Blackwell Scientific Publications. |
| مواضيع طبية MeSH: | Analgesics, Opioid/*pharmacokinetics , Blood Specimen Collection/*veterinary , Buprenorphine/*pharmacokinetics , Cats/*blood, Administration, Buccal ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/blood ; Animals ; Blood Specimen Collection/methods ; Buprenorphine/administration & dosage ; Buprenorphine/blood ; Carotid Arteries ; Extremities/blood supply ; Injections, Intravenous ; Jugular Veins/drug effects ; Jugular Veins/metabolism ; Male |
| مستخلص: | The aim of this study was to examine the effect of the sampling site on the drug concentration-time profile, following intravenous or buccal (often called 'oral transmucosal') drug administration. Buprenorphine (20 μg/kg) was administered IV or buccally to six cats. Blood samples were collected from the carotid artery and the jugular and medial saphenous veins for 24 h following buprenorphine administration. Buprenorphine concentration-time data were examined using noncompartmental analysis. Pharmacokinetic parameters were compared using the Wilcoxon signed rank test, applying the Bonferroni correction. Significance was set at P < 0.05. Following IV administration, no difference among the sampling sites was found. Following buccal administration, maximum concentration [jugular: 6.3 (2.9-9.8), carotid: 3.4 (1.9-4.9), medial saphenous: 2.5 (1.7-4.1) ng/mL], area under the curve [jugular: 395 (335-747), carotid: 278 (214-693), medial saphenous: 255 (188-608) ng·min/mL], and bioavailability [jugular: 47 (34-67), carotid: 32 (20-52), medial saphenous: 23 (16-55)%] were higher in the jugular vein than in the carotid artery and medial saphenous vein. Jugular venous blood sampling is not an acceptable substitute for arterial blood sampling following buccal drug administration. |
| المشرفين على المادة: | 0 (Analgesics, Opioid) 40D3SCR4GZ (Buprenorphine) |
| تواريخ الأحداث: | Date Created: 20140419 Date Completed: 20141103 Latest Revision: 20190923 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/jvp.12075 |
| PMID: | 24745064 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1365-2885 |
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| DOI: | 10.1111/jvp.12075 |