دورية أكاديمية
Dermoscopic criteria associated with BRAF and NRAS mutation status in primary cutaneous melanoma.
| العنوان: | Dermoscopic criteria associated with BRAF and NRAS mutation status in primary cutaneous melanoma. |
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| المؤلفون: | Pozzobon FC; Dermatology Department, Melanoma Unit, Hospital Clinic & IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain; National University of Colombia, Bogotá, Colombia., Puig-Butillé JA, González-Alvarez T, Carrera C, Aguilera P, Alos L, Badenas C, Grichnik JM, Malvehy J, Puig S |
| المصدر: | The British journal of dermatology [Br J Dermatol] 2014 Oct; Vol. 171 (4), pp. 754-9. Date of Electronic Publication: 2014 Sep 10. |
| نوع المنشور: | Journal Article; Observational Study; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0004041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2133 (Electronic) Linking ISSN: 00070963 NLM ISO Abbreviation: Br J Dermatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : Oxford : Oxford University Press Original Publication: Oxford [etc.] Published for the British Association of Dermatologists by Blackwell Scientific Publications [etc.] |
| مواضيع طبية MeSH: | Genes, ras/*genetics , Melanoma/*genetics , Mutation/*genetics , Proto-Oncogene Proteins B-raf/*genetics , Skin Neoplasms/*genetics, Dermoscopy ; Female ; Humans ; Male ; Melanoma/pathology ; Middle Aged ; Retrospective Studies ; Skin Neoplasms/pathology |
| مستخلص: | Background: The identification of BRAF mutations in melanoma led to the development and implementation of new and effective therapies. Few clinical and histological features have been associated with this mutational status. Objectives: The main objective of this study was to investigate clinical, histopathological and dermoscopic characteristics of primary melanomas according to BRAF or NRAS mutational status. Methods: An observational retrospective study including melanoma dermoscopy images assessed for somatic mutations in BRAF and NRAS. Results: Seventy-two patients were included, 30 women (42%) and 42 men (58%), mean age was 59 ± 15.51 years. BRAF-mutated melanomas were more frequently located on the trunk (n = 18, 64% for BRAF-mutated vs. n = 11, 29% for wild-type melanomas, P = 0.013). Histological ulceration was associated with the presence of BRAF mutations [odds ratio (OR) 3.141; 95% confidence interval (CI) 1.289-7.655; P = 0.002]. The Breslow index tended to be thicker in BRAF-mutated compared with wild-type (P = 0.086). BRAF mutations were present in 28 (39%) patients and only four cases were positive for NRAS mutations (6%), BRAF and NRAS mutations being mutually exclusive. The presence of dermoscopic peppering was associated with MAPK mutations (BRAF and NRAS) (OR 1.68; 95% CI 1.089-2.581; P = 0.015). Dermoscopic ulceration was also associated with BRAF mutations excluding acral and facial melanomas (OR 2.64; 95% CI 1.032-6.754). Conclusions: This study showed a correlation between BRAF and NRAS status and dermoscopic findings of 'peppering' as an expression of regression and melanophages in the dermis, suggesting a morphological consequence of immune behaviour in BRAF-mutated melanomas. (© 2014 British Association of Dermatologists.) |
| المشرفين على المادة: | EC 2.7.11.1 (Proto-Oncogene Proteins B-raf) |
| تواريخ الأحداث: | Date Created: 20140423 Date Completed: 20150707 Latest Revision: 20141016 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1111/bjd.13069 |
| PMID: | 24749938 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1365-2133 |
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| DOI: | 10.1111/bjd.13069 |