دورية أكاديمية
Hybridization capture reveals evolution and conservation across the entire Koala retrovirus genome.
العنوان: | Hybridization capture reveals evolution and conservation across the entire Koala retrovirus genome. |
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المؤلفون: | Tsangaras K; Department of Wildlife Diseases, Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany., Siracusa MC; Department of Biological Science and Center for Applied Biotechnology Studies, California State University, Fullerton, California, United States of America., Nikolaidis N; Department of Biological Science and Center for Applied Biotechnology Studies, California State University, Fullerton, California, United States of America., Ishida Y; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America., Cui P; Department of Biological Science and Center for Applied Biotechnology Studies, California State University, Fullerton, California, United States of America., Vielgrader H; Zoo Vienna, Vienna, Austria., Helgen KM; National Museum of Natural History, Smithsonian Institution, Washington, DC, United States of America., Roca AL; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America., Greenwood AD; Department of Biological Science and Center for Applied Biotechnology Studies, California State University, Fullerton, California, United States of America. |
المصدر: | PloS one [PLoS One] 2014 Apr 21; Vol. 9 (4), pp. e95633. Date of Electronic Publication: 2014 Apr 21 (Print Publication: 2014). |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
مواضيع طبية MeSH: | Evolution, Molecular*, Conserved Sequence/*genetics , Genome, Viral/*genetics , Nucleic Acid Hybridization/*genetics , Phascolarctidae/*virology , Retroviridae/*genetics, Animals ; Binding Sites ; Codon/genetics ; Models, Molecular ; Polymorphism, Genetic ; Protein Binding ; Protein Structure, Tertiary ; Proviruses/genetics ; Sequence Alignment ; Terminal Repeat Sequences/genetics ; Transcription Factors/metabolism ; Virus Integration/genetics |
مستخلص: | The koala retrovirus (KoRV) is the only retrovirus known to be in the midst of invading the germ line of its host species. Hybridization capture and next generation sequencing were used on modern and museum DNA samples of koala (Phascolarctos cinereus) to examine ca. 130 years of evolution across the full KoRV genome. Overall, the entire proviral genome appeared to be conserved across time in sequence, protein structure and transcriptional binding sites. A total of 138 polymorphisms were detected, of which 72 were found in more than one individual. At every polymorphic site in the museum koalas, one of the character states matched that of modern KoRV. Among non-synonymous polymorphisms, radical substitutions involving large physiochemical differences between amino acids were elevated in env, potentially reflecting anti-viral immune pressure or avoidance of receptor interference. Polymorphisms were not detected within two functional regions believed to affect infectivity. Host sequences flanking proviral integration sites were also captured; with few proviral loci shared among koalas. Recently described variants of KoRV, designated KoRV-B and KoRV-J, were not detected in museum samples, suggesting that these variants may be of recent origin. |
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معلومات مُعتمدة: | R01 GM092706 United States GM NIGMS NIH HHS; United States HHMI Howard Hughes Medical Institute; R01GM092706 United States GM NIGMS NIH HHS |
المشرفين على المادة: | 0 (Codon) 0 (Transcription Factors) |
تواريخ الأحداث: | Date Created: 20140423 Date Completed: 20150114 Latest Revision: 20211021 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC3994108 |
DOI: | 10.1371/journal.pone.0095633 |
PMID: | 24752422 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1932-6203 |
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DOI: | 10.1371/journal.pone.0095633 |