دورية أكاديمية
Practically convenient and industrially-aligned methods for iridium-catalysed hydrogen isotope exchange processes.
| العنوان: | Practically convenient and industrially-aligned methods for iridium-catalysed hydrogen isotope exchange processes. |
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| المؤلفون: | Cochrane AR; Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK. w.kerr@strath.ac.uk., Idziak C, Kerr WJ, Mondal B, Paterson LC, Tuttle T, Andersson S, Nilsson GN |
| المصدر: | Organic & biomolecular chemistry [Org Biomol Chem] 2014 Jun 14; Vol. 12 (22), pp. 3598-603. Date of Electronic Publication: 2014 Apr 22. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0539 (Electronic) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, UK : Royal Society of Chemistry, c2003- |
| مواضيع طبية MeSH: | Chemistry, Organic/*methods , Deuterium Exchange Measurement/*methods , Hydrogen/*chemistry , Iridium/*chemistry, Anilides/chemistry ; Catalysis ; Molecular Conformation ; Niclosamide/chemistry ; Solvents/chemistry |
| مستخلص: | The use of alternative solvents in the iridium-catalysed hydrogen isotope exchange reaction with developing phosphine/NHC Ir(I) complexes has identified reaction media which are more widely applicable and industrially acceptable than the commonly employed chlorinated solvent, dichloromethane. Deuterium incorporation into a variety of substrates has proceeded to deliver high levels of labelling (and regioselectivity) in the presence of low catalyst loadings and over short reaction times. The preparative outputs have been complemented by DFT studies to explore ligand orientation, as well as solvent and substrate binding energies within the catalyst system. |
| المشرفين على المادة: | 0 (Anilides) 0 (Solvents) 44448S9773 (Iridium) 7YNJ3PO35Z (Hydrogen) 8KK8CQ2K8G (Niclosamide) AK1B12366O (benzanilide) |
| تواريخ الأحداث: | Date Created: 20140424 Date Completed: 20150421 Latest Revision: 20140515 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1039/c4ob00465e |
| PMID: | 24756541 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1477-0539 |
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| DOI: | 10.1039/c4ob00465e |