دورية أكاديمية
Risk factors for juvenile dermatomyositis: exposure to tobacco and air pollutants during pregnancy.
| العنوان: | Risk factors for juvenile dermatomyositis: exposure to tobacco and air pollutants during pregnancy. |
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| المؤلفون: | Orione MA, Silva CA, Sallum AM, Campos LM, Omori CH, Braga AL, Farhat SC |
| المصدر: | Arthritis care & research [Arthritis Care Res (Hoboken)] 2014 Oct; Vol. 66 (10), pp. 1571-5. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101518086 Publication Model: Print Cited Medium: Internet ISSN: 2151-4658 (Electronic) Linking ISSN: 2151464X NLM ISO Abbreviation: Arthritis Care Res (Hoboken) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hoboken, NJ : John Wiley & Sons |
| مواضيع طبية MeSH: | Prenatal Exposure Delayed Effects*, Air Pollutants, Occupational/*adverse effects , Dermatomyositis/*etiology , Inhalation Exposure/*adverse effects , Maternal Exposure/*adverse effects , Occupational Exposure/*adverse effects , Smoking/*adverse effects , Tobacco Smoke Pollution/*adverse effects, Adolescent ; Brazil ; Carbon Monoxide/adverse effects ; Case-Control Studies ; Chi-Square Distribution ; Child ; Child, Preschool ; Dermatomyositis/diagnosis ; Female ; Gestational Age ; Humans ; Infant ; Logistic Models ; Male ; Multivariate Analysis ; Odds Ratio ; Pregnancy ; Risk Factors ; Surveys and Questionnaires ; Urban Health |
| مستخلص: | Objective: To evaluate the influence of exposure to inhaled environmental factors during pregnancy on the diagnosis of juvenile dermatomyositis (DM). Methods: We performed a case–control study comprising 20 juvenile DM patients and 56 healthy controls matched by age and sex who were residents in the metropolitan region of a large city. A questionnaire assessed demographic data and environmental inhalation exposure during pregnancy (occupational exposure to demolition, chalk, construction and/or quarry dust, paints, varnish, gasoline vapor, and/or battery fluids; stationary sources of inhaled pollution near the mother's home; and maternal tobacco exposure). Daily concentrations of inhaled particulate matter, SO2, NO2, O3, and carbon monoxide (CO) were evaluated throughout the gestational period. Results: Maternal occupational exposure to school chalk dust/gasoline vapor in the juvenile DM group was significantly higher compared with controls (50% versus 4.6%; P = 0.001). Smoking mothers and secondhand smoke exposure at home during pregnancy were significantly higher in the juvenile DM group versus controls (smoking mothers: 20% versus 1.7%; P = 0.01, and secondhand smoke: 35% versus 19%; P = 0.07). In univariate logistic regression models, maternal smoking, occupational exposure to inhaled agents, and the highest tertile of tropospheric CO (3.2–5.4 parts per million) in the third trimester were significantly associated with juvenile DM (P ≤ 0.05). In the multivariate analysis, smoking mother (odds ratio [OR] 13.26 [95% confidence interval (95% CI) 1.21–144.29], P = 0.03), occupational exposure (OR 35.39 [95% CI 1.97–632.80], P = 0.01), and CO (third tertile) exposure in the third trimester of gestation (OR 12.21 [95% CI 1.28–115.96], P = 0.03) remained risk factors for juvenile DM. Conclusion: Inhaled pollutants and tobacco smoking during fetal development may contribute to juvenile DM. |
| المشرفين على المادة: | 0 (Air Pollutants, Occupational) 0 (Tobacco Smoke Pollution) 7U1EE4V452 (Carbon Monoxide) |
| SCR Disease Name: | Amyopathic dermatomyositis |
| تواريخ الأحداث: | Date Created: 20140424 Date Completed: 20150206 Latest Revision: 20151119 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1002/acr.22358 |
| PMID: | 24757124 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2151-4658 |
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| DOI: | 10.1002/acr.22358 |