دورية أكاديمية
أعرض في EDS

A benzoic acid derivative and flavokawains from Piper species as schistosomiasis vector controls.

التفاصيل البيبلوغرافية
العنوان: A benzoic acid derivative and flavokawains from Piper species as schistosomiasis vector controls.
المؤلفون: Rapado LN; Laboratório de Parasitologia, Instituto Butantan, Av. Vital Brasil, 1500, São Paulo, SP, CEP 05503-900, Brazil. ludmilanr@usp.br., Freitas GC; Research Support Center in Diversity of Natural Products, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, sala 1124, São Paulo, SP, CEP 05508-000, Brazil. giovanacf@gmail.com., Polpo A; Departamento de Estatística, Centro de Ciências Exatas e de Tecnologia, Universidade Federal de São Carlos, Via Washington Luís, km 235, Sao Carlos, SP, Caixa-postal 676, CEP 13565-905, Brazil. polpo@ufscar.br., Rojas-Cardozo M; Department of Pharmacy, Faculty of Sciences, Universidad Nacional de Colombia, Kr 30 45-03, Bogotá, Colombia., Rincón JV; Department of Pharmacy, Faculty of Sciences, Universidad Nacional de Colombia, Kr 30 45-03, Bogotá, Colombia. jrinconv@unal.edu.co., Scotti MT; Centro de Ciências Aplicadas e Educação, Universidade Federal da Paraíba, Campus IV, Rua da Mangueira, s/n, Rio Tinto, PB, CEP 5829-7000, Brazil. mtscotti@gmail.com., Kato MJ; Research Support Center in Diversity of Natural Products, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, sala 1124, São Paulo, SP, CEP 05508-000, Brazil. majokato@iq.usp.br., Nakano E; Laboratório de Parasitologia, Instituto Butantan, Av. Vital Brasil, 1500, São Paulo, SP, CEP 05503-900, Brazil. eliananakano@butantan.gov.br., Yamaguchi LF; Research Support Center in Diversity of Natural Products, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, sala 1124, São Paulo, SP, CEP 05508-000, Brazil.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2014 Apr 23; Vol. 19 (4), pp. 5205-18. Date of Electronic Publication: 2014 Apr 23.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Antiparasitic Agents/*chemistry , Benzoic Acid/*chemistry , Chalcones/*chemistry , Life Cycle Stages/*drug effects , Piper/*chemistry , Plant Extracts/*chemistry , Snails/*drug effects, Animals ; Antiparasitic Agents/isolation & purification ; Antiparasitic Agents/pharmacology ; Biological Products/chemistry ; Chalcones/isolation & purification ; Chalcones/pharmacology ; Disease Reservoirs ; Humans ; Inhibitory Concentration 50 ; Molecular Docking Simulation ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Plant Leaves/chemistry ; Schistosoma mansoni/physiology ; Schistosomiasis/prevention & control ; Schistosomiasis/transmission ; Snails/growth & development ; Structure-Activity Relationship
مستخلص: The search of alternative compounds to control tropical diseases such as schistosomiasis has pointed to secondary metabolites derived from natural sources. Piper species are candidates in strategies to control the transmission of schistosomiasis due to their production of molluscicidal compounds. A new benzoic acid derivative and three flavokawains from Piper diospyrifolium, P. cumanense and P. gaudichaudianum displayed significant activities against Biomphalaria glabrata snails. Additionally, "in silico" studies were performed using docking assays and Molecular Interaction Fields to evaluate the physical-chemical differences among the compounds in order to characterize the observed activities of the test compounds against Biomphalaria glabrata snails.
References: Phytochemistry. 2002 Feb;59(4):429-33. (PMID: 11830162)
Parasitol Today. 1998 Oct;14(10):413-7. (PMID: 17040832)
J Helminthol. 2011 Mar;85(1):66-72. (PMID: 20444299)
Acta Trop. 2000 Oct 23;77(1):41-51. (PMID: 10996119)
J Cell Sci. 2003 Feb 15;116(Pt 4):585-6. (PMID: 12538758)
PLoS Negl Trop Dis. 2013 Jun 06;7(6):e2251. (PMID: 23755312)
Parasitol Today. 1999 Oct;15(10):395-7. (PMID: 10481149)
J Med Chem. 2006 Jun 1;49(11):3315-21. (PMID: 16722650)
Bull World Health Organ. 1965;33(4):567-81. (PMID: 5295001)
World Health Organ Tech Rep Ser. 1993;830:1-86. (PMID: 8322462)
J Mol Biol. 2005 Dec 9;354(4):841-53. (PMID: 16274693)
World Health Organ Tech Rep Ser. 2002;912:i-vi, 1-57, back cover. (PMID: 12592987)
المشرفين على المادة: 0 (Antiparasitic Agents)
0 (Biological Products)
0 (Chalcones)
0 (Plant Extracts)
8SKN0B0MIM (Benzoic Acid)
تواريخ الأحداث: Date Created: 20140426 Date Completed: 20141125 Latest Revision: 20211021
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6271750
DOI: 10.3390/molecules19045205
PMID: 24762961
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules19045205