دورية أكاديمية
Quiescence-induced LncRNAs trigger H4K20 trimethylation and transcriptional silencing.
| العنوان: | Quiescence-induced LncRNAs trigger H4K20 trimethylation and transcriptional silencing. |
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| المؤلفون: | Bierhoff H; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany., Dammert MA; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany., Brocks D; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany., Dambacher S; Adolf Butenandt Institute and Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universität, 80336 Munich, Germany., Schotta G; Adolf Butenandt Institute and Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universität, 80336 Munich, Germany., Grummt I; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany. Electronic address: i.grummt@dkfz.de. |
| المصدر: | Molecular cell [Mol Cell] 2014 May 22; Vol. 54 (4), pp. 675-82. Date of Electronic Publication: 2014 Apr 24. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge Ma : Cell Press Original Publication: Cambridge, Mass. : Cell Press, c1997- |
| مواضيع طبية MeSH: | Gene Silencing* , Genes, rRNA*, Chromatin/*metabolism , Histone-Lysine N-Methyltransferase/*metabolism , Histones/*metabolism , Lysine/*metabolism , RNA, Long Noncoding/*metabolism, Animals ; Cell Proliferation ; Chromatin/genetics ; Gene Expression Regulation ; Genes, Intracisternal A-Particle ; Genetic Loci ; Histone-Lysine N-Methyltransferase/genetics ; Histones/chemistry ; Histones/genetics ; Methylation ; Mice ; NIH 3T3 Cells ; RNA, Long Noncoding/genetics ; Telomere/genetics |
| مستخلص: | A complex network of regulatory pathways links transcription to cell growth and proliferation. Here we show that cellular quiescence alters chromatin structure by promoting trimethylation of histone H4 at lysine 20 (H4K20me3). In contrast to pericentric or telomeric regions, recruitment of the H4K20 methyltransferase Suv4-20h2 to rRNA genes and IAP elements requires neither trimethylation of H3K9 nor interaction with HP1 proteins but depends on long noncoding RNAs (lncRNAs) that interact with Suv4-20h2. Growth factor deprivation and terminal differentiation lead to upregulation of these lncRNAs, increase in H4K20me3, and chromatin compaction. The results uncover a lncRNA-mediated mechanism that guides Suv4-20h2 to specific genomic loci to establish a more compact chromatin structure in growth-arrested cells. (Copyright © 2014 Elsevier Inc. All rights reserved.) |
| المشرفين على المادة: | 0 (Chromatin) 0 (Histones) 0 (RNA, Long Noncoding) 0 (Suv4-20h protein, mouse) EC 2.1.1.43 (Histone-Lysine N-Methyltransferase) K3Z4F929H6 (Lysine) |
| تواريخ الأحداث: | Date Created: 20140429 Date Completed: 20140708 Latest Revision: 20190327 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.molcel.2014.03.032 |
| PMID: | 24768537 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1097-4164 |
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| DOI: | 10.1016/j.molcel.2014.03.032 |