دورية أكاديمية
Retinal pigment epithelium rips after ranibizumab in neovascular age-related macular degeneration: incidence, risk factors and long-term outcome.
| العنوان: | Retinal pigment epithelium rips after ranibizumab in neovascular age-related macular degeneration: incidence, risk factors and long-term outcome. |
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| المؤلفون: | Guber J; Sutton Eye Hospital, Epsom and St. Helier University Hospital (Lead Clinician: Miss Jane Leitch), London, UK., Praveen A; Sutton Eye Hospital, Epsom and St. Helier University Hospital (Lead Clinician: Miss Jane Leitch), London, UK., Saeed MU; Sutton Eye Hospital, Epsom and St. Helier University Hospital (Lead Clinician: Miss Jane Leitch), London, UK. |
| المصدر: | Klinische Monatsblatter fur Augenheilkunde [Klin Monbl Augenheilkd] 2014 Apr; Vol. 231 (4), pp. 432-5. Date of Electronic Publication: 2014 Apr 25. |
| نوع المنشور: | Clinical Trial; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Thieme Country of Publication: Germany NLM ID: 0014133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-3999 (Electronic) Linking ISSN: 00232165 NLM ISO Abbreviation: Klin Monbl Augenheilkd Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Stuttgart : Thieme Original Publication: Stuttgart. |
| مواضيع طبية MeSH: | Antibodies, Monoclonal, Humanized/*adverse effects , Antibodies, Monoclonal, Humanized/*therapeutic use , Choroidal Neovascularization/*drug therapy , Retinal Detachment/*chemically induced , Retinal Detachment/*pathology , Wet Macular Degeneration/*diagnosis , Wet Macular Degeneration/*drug therapy, Aged ; Aged, 80 and over ; Angiogenesis Inhibitors/adverse effects ; Angiogenesis Inhibitors/therapeutic use ; Causality ; Choroidal Neovascularization/complications ; Comorbidity ; Female ; Humans ; Incidence ; Longitudinal Studies ; Male ; Ranibizumab ; Reproducibility of Results ; Risk Factors ; Sensitivity and Specificity ; Tomography, Optical Coherence/statistics & numerical data ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Vision Disorders ; Wet Macular Degeneration/complications |
| مستخلص: | Background: Retinal pigment epithelium (RPE) rips after ranibizumab for wet age related macular degeneration (AMD) with a pigment epithelial detachments (PED) are a dreaded complication. Aim of this study was to analyse the incidence, the risk factors and long-term outcome after a PED tear. Patients and Methods: 401 patients with wet AMD were analysed. A total of 33 eyes with PED were identified. Mean follow up time was 635 days (SD ± 311). Results: PED tears occurred in 8 (24%) patients. Most RPE rips (40%) occurred within the first three months. Mean visual loss was 13 letters (range -57-9). The PED tear group had a mean PED height of 521 µm. The PED group without a tear had a mean height of 300 µm (p ≤ 0.001). Patients with a PED height over 300 µm had more than twice the risk to develop a RPE rip compared to patients with PED height smaller than 300 µm (p ≤ 0.001). Conclusions: PED height is a relevant factor for the incidence of RPE rips after treatment with ranibizumab. Owing to the close time relationship with the therapy, this complication must be taken into account before treatment as it may lead to significant vision loss. (Georg Thieme Verlag KG Stuttgart · New York.) |
| المشرفين على المادة: | 0 (Angiogenesis Inhibitors) 0 (Antibodies, Monoclonal, Humanized) 0 (Vascular Endothelial Growth Factor A) ZL1R02VT79 (Ranibizumab) |
| تواريخ الأحداث: | Date Created: 20140429 Date Completed: 20141218 Latest Revision: 20151119 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1055/s-0034-1368219 |
| PMID: | 24771185 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1439-3999 |
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| DOI: | 10.1055/s-0034-1368219 |