دورية أكاديمية
أعرض في EDS

Serum cytokines are increased and circulating micronutrients are not altered in subjects with early compared to advanced knee osteoarthritis.

التفاصيل البيبلوغرافية
العنوان: Serum cytokines are increased and circulating micronutrients are not altered in subjects with early compared to advanced knee osteoarthritis.
المؤلفون: Barker T; The Orthopedic Specialty Hospital, Murray, UT 84107, USA. Electronic address: tyler.barker@imail.org., Rogers VE; The Orthopedic Specialty Hospital, Murray, UT 84107, USA., Henriksen VT; The Orthopedic Specialty Hospital, Murray, UT 84107, USA; The Orthopedic Specialty Clinic, Murray, UT 84107, USA., Aguirre D; The Orthopedic Specialty Hospital, Murray, UT 84107, USA., Trawick RH; The Orthopedic Specialty Hospital, Murray, UT 84107, USA; The Orthopedic Specialty Clinic, Murray, UT 84107, USA., Rasmussen GL; The Orthopedic Specialty Hospital, Murray, UT 84107, USA; The Orthopedic Specialty Clinic, Murray, UT 84107, USA., Momberger NG; The Orthopedic Specialty Hospital, Murray, UT 84107, USA; The Orthopedic Specialty Clinic, Murray, UT 84107, USA.
المصدر: Cytokine [Cytokine] 2014 Aug; Vol. 68 (2), pp. 133-6. Date of Electronic Publication: 2014 Apr 29.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005353 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0023 (Electronic) Linking ISSN: 10434666 NLM ISO Abbreviation: Cytokine Subsets: MEDLINE
أسماء مطبوعة: Publication: <2001- > : Oxford : Elsevier Science Ltd.
Original Publication: [Philadelphia, PA] : Saunders Scientific Publications, W.B. Saunders, [c1989-
مواضيع طبية MeSH: Cytokines/*blood , Micronutrients/*blood , Osteoarthritis, Knee/*blood, Adult ; Female ; Humans ; Leg/physiopathology ; Male ; Osteoarthritis, Knee/pathology ; Osteoarthritis, Knee/physiopathology
مستخلص: Knee osteoarthritis (OA) is a leading cause of physical disability. At the early stage of knee OA, the increase in synovial fluid cytokine concentrations could contribute to the pathogenesis of OA by degrading articular cartilage. It is unknown, however, if inflammatory cytokines increase systemically at the early or advanced stage of knee OA. The systemic increase of inflammatory cytokines could be detrimental to the endogenous status of micronutrients that protect against excessive inflammation and cytokine-mediated events. The purpose of this study was to test the hypothesis that an increase in serum cytokines associate with a decrease in circulating micronutrients in subjects with early compared to advanced knee OA. Advanced knee OA subjects (n=14) displayed radiographic, pain, and muscular weakness symptoms of knee OA. Early knee OA subjects (n=14) were matched (age, gender, and body mass index) to the advanced OA group and displayed one or two of the aforementioned symptoms of knee OA. Inflammatory cytokines, vitamins C (ascorbic acid), D (25-hydroxyvitamin D), and E (α- and γ-tocopherols), and β-carotene were measured in fasting blood samples. In the early OA group, serum tumor necrosis factor (TNF)-α, interleukin (IL)-5, IL-6, IL-12, and IL-13 concentrations were significantly (all p<0.05) increased. Circulating ascorbic acid, 25-hydroxyvitamin D, α- and γ-tocopherol's, and β-carotene concentrations were not significantly different between groups. Based on these preliminary results, we conclude that the systemic increase of inflammatory cytokines is not associated with a decrease in circulating micronutrients in subjects with early compared to advanced knee OA.
(Copyright © 2014 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Cytokines; Knee osteoarthritis; Micronutrients
المشرفين على المادة: 0 (Cytokines)
0 (Micronutrients)
تواريخ الأحداث: Date Created: 20140503 Date Completed: 20141230 Latest Revision: 20140521
رمز التحديث: 20240829
DOI: 10.1016/j.cyto.2014.04.004
PMID: 24787465
قاعدة البيانات: MEDLINE
الوصف
تدمد:1096-0023
DOI:10.1016/j.cyto.2014.04.004