دورية أكاديمية
Exercise capacity in polycystic kidney disease.
| العنوان: | Exercise capacity in polycystic kidney disease. |
|---|---|
| المؤلفون: | Reinecke NL; Renal Division, Department of Medicine, Federal University of São Paulo, São Paulo, Brazil., Cunha TM; Pneumology Division, Department of Medicine, Federal University of São Paulo, São Paulo, Brazil., Heilberg IP; Renal Division, Department of Medicine, Federal University of São Paulo, São Paulo, Brazil., Higa EM; Renal Division, Department of Medicine, Federal University of São Paulo, São Paulo, Brazil., Nishiura JL; Renal Division, Department of Medicine, Federal University of São Paulo, São Paulo, Brazil., Neder JA; Pneumology Division, Department of Medicine, Federal University of São Paulo, São Paulo, Brazil., Almeida WS; Renal Division, Department of Medicine, Federal University of São Paulo, São Paulo, Brazil., Schor N; Renal Division, Department of Medicine, Federal University of São Paulo, São Paulo, Brazil. Electronic address: nestor@nefro.epm.br. |
| المصدر: | American journal of kidney diseases : the official journal of the National Kidney Foundation [Am J Kidney Dis] 2014 Aug; Vol. 64 (2), pp. 239-46. Date of Electronic Publication: 2014 Apr 29. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: W.B. Saunders Country of Publication: United States NLM ID: 8110075 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-6838 (Electronic) Linking ISSN: 02726386 NLM ISO Abbreviation: Am J Kidney Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Philadelphia Pa : W.B. Saunders Original Publication: New York, N.Y. : Grune & Stratton, c1981- |
| مواضيع طبية MeSH: | Exercise/*physiology , Exercise Tolerance/*physiology , Polycystic Kidney, Autosomal Dominant/*physiopathology, Adult ; Blood Pressure/physiology ; Cohort Studies ; Female ; Follow-Up Studies ; Heart Rate/physiology ; Humans ; Male ; Polycystic Kidney, Autosomal Dominant/diagnosis ; Prospective Studies ; Young Adult |
| مستخلص: | Background: Reports about exercise performance in autosomal dominant polycystic kidney disease (ADPKD) are scarce. We aimed to evaluate exercise capacity and levels of nitric oxide and asymmetric dimethylarginine (ADMA) in normotensive patients with ADPKD. Study Design: Prospective controlled cohort study. Setting & Participants: 26 patients with ADPKD and 30 non-ADPKD control participants (estimated glomerular filtration rate>60 mL/min/1.73 m2, aged 19-39 years, and blood pressure [BP]<140/85 mmHg). We excluded smokers, obese people, and individuals with associated diseases. Predictor: ADPKD versus control. Outcomes: Exercise capacity and nitric oxide and ADMA levels in response to exercise. Measurements: Cardiopulmonary exercise testing and serum and urinary nitric oxide, plasma ADMA, and BP levels before and after exercise. Results: Mean basal systolic and diastolic BP, estimated glomerular filtration rate, and age did not differ between the ADPKD and control groups (116±12 vs. 110±11 mmHg, 76±11 vs 71±9 mmHg, 113±17 vs. 112±9.6 mL/min/1.73 m2, and 30±8 vs. 28.9±7.3 years, respectively). Peak oxygen uptake and anaerobic threshold were significantly lower in the ADPKD group than in controls (22.2±3.3 vs. 31±4.8 mL/kg/min [P<0.001] and 743.6±221 vs. 957.4±301 L/min [P=0.01], respectively). Postexercise serum and urinary nitric oxide levels in patients with ADPKD were not significantly different from baseline (45±5.1 vs. 48.3±4.6 μmol/L and 34.7±6.5 vs. 39.8±6.8 μmol/mg of creatinine, respectively), contrasting with increased postexercise values in controls (63.1±1.9 vs. 53.9±3.1 μmol/L [P=0.01] and 61.4±10.6 vs. 38.7±5.6 μmol/mg of creatinine [P=0.01], respectively). Similarly, whereas postexercise ADMA level did not change in the ADPKD group compared to those at rest (0.47±0.04 vs. 0.45±0.02 μmol/L [P=0.6]), it decreased in controls (0.39±0.02 vs. 0.47±0.02 μmol/L [P=0.006]), as expected. A negative correlation between nitric oxide and ADMA levels after exercise was found in only the control group (r = -0.60; P<0.01). Limitations: Absence of measurements of flow-mediated dilatation and oxidative status. Conclusions: We found lower aerobic capacity in young normotensive patients with ADPKD with preserved kidney function and inadequate responses of nitric oxide and ADMA levels to acute exercise, suggesting the presence of early endothelial dysfunction in this disease. (Copyright © 2014 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Autosomal dominant polycystic kidney disease (ADPKD); asymmetric dimethylarginine (ADMA); cardiopulmonary exercise testing; cystic diseases; exercise; nitric oxide; physical capacity; polycystic kidney |
| تواريخ الأحداث: | Date Created: 20140503 Date Completed: 20140922 Latest Revision: 20140725 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1053/j.ajkd.2014.03.014 |
| PMID: | 24787761 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1523-6838 |
|---|---|
| DOI: | 10.1053/j.ajkd.2014.03.014 |