دورية أكاديمية
أعرض في EDS

Mucin gene expression in reflux laryngeal mucosa: histological and in situ hybridization observations.

التفاصيل البيبلوغرافية
العنوان: Mucin gene expression in reflux laryngeal mucosa: histological and in situ hybridization observations.
المؤلفون: Ali Mel-S; Department of Otolaryngology, Mansoura University Hospital, Mansoura University, Egypt ; Institute for Cell and Molecular Biosciences, Newcastle University, Faculty of Medical Sciences, Newcastle upon Tyne NE2 4HH, UK., Bulmer DM; Institute for Cell and Molecular Biosciences, Newcastle University, Faculty of Medical Sciences, Newcastle upon Tyne NE2 4HH, UK., Dettmar PW; Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK., Pearson JP; Institute for Cell and Molecular Biosciences, Newcastle University, Faculty of Medical Sciences, Newcastle upon Tyne NE2 4HH, UK.
المصدر: International journal of otolaryngology [Int J Otolaryngol] 2014; Vol. 2014, pp. 264075. Date of Electronic Publication: 2014 Mar 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101518366 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1687-9201 (Print) Linking ISSN: 16879201 NLM ISO Abbreviation: Int J Otolaryngol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Hindawi Pub. Corp.
مستخلص: Objectives/Hypothesis. To determine if laryngopharyngeal reflux alters mucin gene expression in laryngeal mucosa. Methods. In situ hybridization was employed to study the expression of the 8 well-characterised mucin genes MUC1-4, 5AC, 5B, 6, and 7 in reflux laryngeal mucosa from laryngeal ventricles, posterior commissures, and vocal folds compared to control/normal laryngeal mucosa. Results. MUC1-5 genes are expressed in normal and reflux laryngeal mucosa. MUC1, 3 and 4 are expressed in respiratory and squamous mucosa whereas MUC2 and 5AC are expressed in respiratory mucosa only. MUC3, 4 and 5AC are downregulated in reflux mucosa. MUC5AC expression is significantly reduced in the 3 mucosal sites and when mucosal type was taken into account, this remains significant in combined laryngeal and ventricular mucosa only. Conclusions. MUC3, 4 and 5AC expression is downregulated in laryngopharyngeal reflux. This may be due to laryngeal mucosal metaplasia and/or alteration of mucin gene expression in the preexisting mucosa. Altered mucin gene expression might predispose laryngeal mucosa to the damaging effect of reflux.
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تواريخ الأحداث: Date Created: 20140503 Date Completed: 20140505 Latest Revision: 20211021
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC3982410
DOI: 10.1155/2014/264075
PMID: 24790604
قاعدة البيانات: MEDLINE
الوصف
تدمد:1687-9201
DOI:10.1155/2014/264075