دورية أكاديمية
[Effect of deltaran and melatonin on immune system in rats with experimental contact dermatitis].
| العنوان: | [Effect of deltaran and melatonin on immune system in rats with experimental contact dermatitis]. |
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| المؤلفون: | Shandra OO |
| المصدر: | Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) [Fiziol Zh (1994)] 2014; Vol. 60 (1), pp. 78-83. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Ukrainian |
| بيانات الدورية: | Publisher: Naukova Dumka Country of Publication: Ukraine NLM ID: 9601541 Publication Model: Print Cited Medium: Print ISSN: 2522-9028 (Print) Linking ISSN: 25229028 NLM ISO Abbreviation: Fiziol Zh (1994) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Kyiv : Naukova Dumka Original Publication: Kyïv : Nauk. dumka, 1994- |
| مواضيع طبية MeSH: | Delta Sleep-Inducing Peptide/*therapeutic use , Dermatitis, Contact/*drug therapy , Glycine/*therapeutic use , Immunity, Cellular/*drug effects , Immunity, Humoral/*drug effects , Melatonin/*therapeutic use, Animals ; Circadian Rhythm/drug effects ; Circadian Rhythm/immunology ; Delta Sleep-Inducing Peptide/administration & dosage ; Dermatitis, Contact/blood ; Dermatitis, Contact/immunology ; Disease Models, Animal ; Drug Combinations ; Drug Therapy, Combination ; Glycine/administration & dosage ; Leukocytes/drug effects ; Leukocytes/immunology ; Male ; Melatonin/administration & dosage ; Rats ; Rats, Wistar ; Treatment Outcome |
| مستخلص: | The aim of the work was investigation of both humoral and cell-mediated immunity together with leukocytes functional stability indexes in rats with the experimental contact dermatitis (ECD) in conditions of complex pharmacological correction using deltaran and melatonin. Experimental trials were performed under conditions of chronic experiment on model chrome-induced ECD. Both deltaran and melatonin either alone or in combination were used for complex pharmacological correction of humoral and cell-mediated immunity and also for stability of leukocytes. The data obtained showed the expressed disturbances of humoral and cell-mediated immunity and neutrophils' functional stability damage under conditions of chrome-induced ECD in rats. The revealed alterations in functional activity of the immune system were successfully corrected using the combined administration of deltaran and melatonin. The activity of medical complex had exponential character. |
| المشرفين على المادة: | 0 (Drug Combinations) 0 (deltaran) 69431-45-4 (Delta Sleep-Inducing Peptide) JL5DK93RCL (Melatonin) TE7660XO1C (Glycine) |
| تواريخ الأحداث: | Date Created: 20140510 Date Completed: 20140605 Latest Revision: 20140509 |
| رمز التحديث: | 20231215 |
| PMID: | 24809178 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2522-9028 |
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