دورية أكاديمية
Fetal outcomes in pregnant women with sickle cell disease.
| العنوان: | Fetal outcomes in pregnant women with sickle cell disease. |
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| المؤلفون: | Al-Farsi SH; Department of Obstetrics and Gynecology, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman., Al-Khabori MK, Al-Hunieni MN, Al-Riyami NM |
| المصدر: | Saudi medical journal [Saudi Med J] 2014 May; Vol. 35 (5), pp. 472-6. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medical Services Department, Saudi Arabian Armed Forces, Ministry Of Defence And Aviation Country of Publication: Saudi Arabia NLM ID: 7909441 Publication Model: Print Cited Medium: Internet ISSN: 1658-3175 (Electronic) Linking ISSN: 03795284 NLM ISO Abbreviation: Saudi Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Riyadh : Medical Services Department, Saudi Arabian Armed Forces, Ministry Of Defence And Aviation Original Publication: Riyadh, Saudi Arabia, Riyadh Al-Kharj Hospital Programme. |
| مواضيع طبية MeSH: | Pregnancy Outcome*, Anemia, Sickle Cell/*physiopathology , Pregnancy Complications, Hematologic/*physiopathology, Adult ; Female ; Humans ; Pregnancy ; Retrospective Studies |
| مستخلص: | Objective: To investigate fetal outcomes in pregnant women with sickle cell disease (SCD), and to analyze the impact of baseline variables on those outcomes. Methods: This is a retrospective cohort study carried out over 5 years (June 2006 to August 2011) investigating fetal outcomes at Sultan Qaboos University Hospital, Muscat, Oman. Sixty-eight consecutive pregnant women with SCD (62 women with hemoglobin sickle cell anemia [SS] genotype) were included and analyzed in the study. Multivariable logistic regression was used to estimate the impact of baseline variables on major fetal complications (intrauterine growth restriction, intrauterine fetal death, and low birth weight babies, perinatal mortality, and admission to the neonatal unit). Results: The mean maternal age was 30 years +/-3.8. Mean gestational age at delivery was 37 weeks +/-1.8. The initial mean hemoglobin was 9.5 g/dl (standard deviation [SD] 1.1, range 7.2-11.9). The mean baseline hemoglobin F was 10.2 (SD 6.6, range 0.7-29). There were 11 cases (16.2%) of intrauterine growth restriction (95% confidence interval [CI]: 7.2-25.2), and 19 cases of fetal distress (27.9%; 95% CI: 17.0-38.9). Low birth weight was seen in 22 cases (32.4%, 95% CI: 20.9-43.8) with a mean weight of 2.6 Kg (SD: 0.47, range 1.2-3.9). There were 2 neonatal deaths. On multivariate logistic regression for a composite of fetal outcomes, none of those variables were of statistical significance. Conclusion: The adverse fetal outcomes in pregnant women with SCD are high compared with the general population. There is no significant difference in fetal outcome between SCD, SS genotype versus others. |
| التعليقات: | Comment in: Saudi Med J. 2014 Sep;35(9):1160-1. (PMID: 25228198) Comment in: Saudi Med J. 2014 Sep;35(9):1160. (PMID: 25360465) |
| تواريخ الأحداث: | Date Created: 20140515 Date Completed: 20150413 Latest Revision: 20140514 |
| رمز التحديث: | 20231215 |
| PMID: | 24825808 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1658-3175 |
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