دورية أكاديمية
أعرض في EDS

Structural and functional brain alterations in end stage renal disease patients on routine hemodialysis: a voxel-based morphometry and resting state functional connectivity study.

التفاصيل البيبلوغرافية
العنوان: Structural and functional brain alterations in end stage renal disease patients on routine hemodialysis: a voxel-based morphometry and resting state functional connectivity study.
المؤلفون: Qiu Y; Department of Medical Imaging, Guangdong No. 2 Provincial People's Hospital, Guangzhou, PR China; Department of Medical Imaging, The First Affiliated Hospital of Gannan Medical University, Ganzhou, PR China., Lv X; Departments of Medical Imaging and Interventional Radiology, Cancer Center, Sun Yat-Sen University, Guangzhou, PR China., Su H; Department of Medical Imaging, Guangdong No. 2 Provincial People's Hospital, Guangzhou, PR China., Jiang G; Department of Medical Imaging, Guangdong No. 2 Provincial People's Hospital, Guangzhou, PR China., Li C; Department of Renal Transplantation, Guangdong No. 2 Provincial People's Hospital, Guangzhou, PR China., Tian J; Department of Medical Imaging, Guangdong No. 2 Provincial People's Hospital, Guangzhou, PR China.
المصدر: PloS one [PLoS One] 2014 May 22; Vol. 9 (5), pp. e98346. Date of Electronic Publication: 2014 May 22 (Print Publication: 2014).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Renal Dialysis*, Brain/*physiopathology , Kidney Failure, Chronic/*physiopathology, Brain/pathology ; Case-Control Studies ; Humans ; Kidney Failure, Chronic/pathology ; Kidney Failure, Chronic/therapy ; Magnetic Resonance Imaging ; Prospective Studies
مستخلص: Background and Purpose: Cognitive impairment is a well-described phenomenon in end-stage renal disease (ESRD) patients. However, its pathogenesis remains poorly understood. The primary focus of this study was to examine structural and functional brain deficits in ESRD patients.
Materials and Methods: Thirty ESRD patients on hemodialysis (without clinical neurological disease) and 30 age- and gender-matched control individuals (without renal or neurological problems) were recruited in a prospective, single-center study. High-resolution structural magnetic resonance imaging (MRI) and resting state functional MRI were performed on both groups to detect the subtle cerebral deficits in ESRD patients. Voxel-based morphometry was used to characterize gray matter deficits in ESRD patients. The impact of abnormal morphometry on the cerebral functional integrity was investigated by evaluating the alterations in resting state functional connectivity when brain regions with gray matter volume reduction were used as seed areas.
Results: A significant decrease in gray matter volume was observed in ESRD patients in the bilateral medial orbito-prefrontal cortices, bilateral dorsal lateral prefrontal cortices, and the left middle temporal cortex. When brain regions with gray matter volume reduction were used as seed areas, the integration was found to be significantly decreased in ESRD patients in the fronto-cerebellum circuits and within prefrontal circuits. In addition, significantly enhanced functional connectivity was found between the prefrontal cortex and the left temporal cortex and within the prefrontal circuits.
Conclusions: Our study revealed that both the structural and functional cerebral cortices were impaired in ESRD patients on routine hemodialysis.
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تواريخ الأحداث: Date Created: 20140524 Date Completed: 20150120 Latest Revision: 20220318
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4031192
DOI: 10.1371/journal.pone.0098346
PMID: 24854737
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0098346