دورية أكاديمية
أعرض في EDS

Chimerin 2 genetic polymorphisms are associated with non-proliferative diabetic retinopathy in Taiwanese type 2 diabetic patients.

التفاصيل البيبلوغرافية
العنوان: Chimerin 2 genetic polymorphisms are associated with non-proliferative diabetic retinopathy in Taiwanese type 2 diabetic patients.
المؤلفون: Chen M; Department of Urology, Mackay Memorial Hospital, Taipei, Taiwan; Mackay Medicine, Nursing and Management College, Taipei, Taiwan; School of Medicine, Mackay Medical College, New Taipei City, Taiwan., Lin WR; Department of Urology, Mackay Memorial Hospital, Taipei, Taiwan., Lu CH; Division of Endocrinology and Metabolism of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan., Chen CC; Division of Endocrinology and Metabolism, Department of Medicine, China Medical University Hospital, Taichung, Taiwan; School of Chinese Medicine, China Medical University, Taichung, Taiwan., Huang YC; School of Chinese Medicine, China Medical University, Taichung, Taiwan; Genetics Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan., Liao WL; Center for Personalized Medicine, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Integrate Medicine, School of Chinese Medicine, China Medical University, Taichung, Taiwan. Electronic address: T12678@mail.cmuh.org.tw., Tsai FJ; School of Chinese Medicine, China Medical University, Taichung, Taiwan; Genetics Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. Electronic address: d0704@www.cmuh.org.tw.
المصدر: Journal of diabetes and its complications [J Diabetes Complications] 2014 Jul-Aug; Vol. 28 (4), pp. 460-3. Date of Electronic Publication: 2014 Apr 18.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Pub. Co Country of Publication: United States NLM ID: 9204583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-460X (Electronic) Linking ISSN: 10568727 NLM ISO Abbreviation: J Diabetes Complications Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Elsevier Science Pub. Co., c1992-
مواضيع طبية MeSH: Polymorphism, Single Nucleotide*, Chimerin Proteins/*genetics , Diabetes Mellitus, Type 2/*complications , Diabetic Retinopathy/*genetics, Aged ; Alleles ; Asian People ; Case-Control Studies ; Chimerin Proteins/metabolism ; China/ethnology ; Cross-Sectional Studies ; Diabetic Retinopathy/metabolism ; Diabetic Retinopathy/pathology ; Diabetic Retinopathy/physiopathology ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Logistic Models ; Male ; Middle Aged ; Retina/pathology ; Severity of Illness Index ; Taiwan
مستخلص: Aim: To investigate whether chimerin 2 (CHN2) genetic polymorphisms were associated with the susceptibility to diabetic retinopathy (DR) in Taiwanese individuals with type 2 diabetes.
Methods: This case-control study comprised of 171 individuals with DR and 548 without DR. Four rs39059, rs2023908, rs1002630 and rs1362363 polymorphism of CHN2 were genotyped for each subjects. All subjects underwent a complete ophthalmologic examination, and basic information (age, gender, age at diagnosis of diabetes, and ocular history of the patient) was record. Several clinical parameters (systolic and diastolic blood pressure, waist and hip circumferences, body mass index levels, fasting glucose and HbA1c) were measured.
Results: Logistic regressions were used to analyze odds ratios between SNPs and DR after controlling for gender, systolic blood pressure, waist and hip ratio, duration of diabetes, serum HbA1c levels and nephropathy classification. A protective effect of rs1002630 (GA+AA) and rs1362363 (AG+GG) [odds ratio (OR) (95% confidence interval)=0.45 (0.22-0.88), 0.66 (0.44-0.99), respectively) was observed. Furthermore, the protective effect of rs1002630 was observed when compared subjects with non-proliferative DR with subjects without DR [OR=0.25 (95%C.I. = 0.09-0.73)].
Conclusions: This study showed that the rs1002630 of CHN2 were associated with DR risk and non-proliferative DR risk in Taiwanese individuals with type 2 diabetes. Variations at this locus may contribute to the pathogenesis of DR.
(Copyright © 2014 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: CHN2; Diabetic retinopathy; Single nucleotide polymorphism; Taiwanese; Type 2 diabetes
المشرفين على المادة: 0 (Chimerin Proteins)
0 (chimaerin-beta3 protein, human)
تواريخ الأحداث: Date Created: 20140524 Date Completed: 20150213 Latest Revision: 20221207
رمز التحديث: 20231215
DOI: 10.1016/j.jdiacomp.2014.04.009
PMID: 24854763
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-460X
DOI:10.1016/j.jdiacomp.2014.04.009