دورية أكاديمية
Mid-range Ca2+ signalling mediated by functional coupling between store-operated Ca2+ entry and IP3-dependent Ca2+ release.
| العنوان: | Mid-range Ca2+ signalling mediated by functional coupling between store-operated Ca2+ entry and IP3-dependent Ca2+ release. |
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| المؤلفون: | Courjaret R; Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, PO Box 24144, Doha, Qatar., Machaca K; Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, PO Box 24144, Doha, Qatar. |
| المصدر: | Nature communications [Nat Commun] 2014 May 28; Vol. 5, pp. 3916. Date of Electronic Publication: 2014 May 28. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
| مواضيع طبية MeSH: | Calcium Signaling*/drug effects, Calcium/*metabolism , Inositol 1,4,5-Trisphosphate/*metabolism, Animals ; Calcium Channels/metabolism ; Cytoplasm/drug effects ; Cytoplasm/metabolism ; Egtazic Acid/analogs & derivatives ; Egtazic Acid/pharmacology ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/metabolism ; Female ; Green Fluorescent Proteins/metabolism ; Heparin/pharmacology ; Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Ion Channel Gating/drug effects ; Membrane Microdomains/drug effects ; Membrane Potentials/drug effects ; Oocytes/drug effects ; Oocytes/metabolism ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism ; Subcellular Fractions/drug effects ; Subcellular Fractions/metabolism ; Xenopus laevis |
| مستخلص: | The versatility and universality of Ca(2+) signals stem from the breadth of their spatial and temporal dynamics. Spatially, Ca(2+) signalling is well studied in the microdomain scale, close to a Ca(2+) channel, and at the whole-cell level. However, little is known about how local Ca(2+) signals are regulated to specifically activate spatially distant effectors without a global Ca(2+) rise. Here we show that an intricate coupling between the inositol 1,4,5 trisphosphate (IP3) receptor, SERCA pump and store-operated Ca(2+) entry (SOCE) allows for efficient mid-range Ca(2+) signalling. Ca(2+) flowing through SOCE is taken up into the ER lumen by the SERCA pump, only to be re-released by IP3Rs to activate distal Ca(2+)-activated Cl(-) channels (CaCCs). This CaCC regulation contributes to setting the membrane potential of the cell. Hence functional coupling between SOCE, SERCA and IP3R limits local Ca(2+) diffusion and funnels Ca(2+) through the ER lumen to activate a spatially separate Ca(2+) effector. |
| المشرفين على المادة: | 0 (Calcium Channels) 0 (Inositol 1,4,5-Trisphosphate Receptors) 147336-22-9 (Green Fluorescent Proteins) 526U7A2651 (Egtazic Acid) 85166-31-0 (Inositol 1,4,5-Trisphosphate) 9005-49-6 (Heparin) EC 3.6.3.8 (Sarcoplasmic Reticulum Calcium-Transporting ATPases) K22DDW77C0 (1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid) SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 20140529 Date Completed: 20151027 Latest Revision: 20140528 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1038/ncomms4916 |
| PMID: | 24867608 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2041-1723 |
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| DOI: | 10.1038/ncomms4916 |