دورية أكاديمية
أعرض في EDS

Capacity of novelty-induced locomotor activity and the hole-board test to predict sensitivity to the conditioned rewarding effects of cocaine.

التفاصيل البيبلوغرافية
العنوان: Capacity of novelty-induced locomotor activity and the hole-board test to predict sensitivity to the conditioned rewarding effects of cocaine.
المؤلفون: Arenas MC; Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universitat de València, Valencia 46010, Spain., Daza-Losada M; Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universitat de València, Valencia 46010, Spain., Vidal-Infer A; Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universitat de València, Valencia 46010, Spain., Aguilar MA; Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universitat de València, Valencia 46010, Spain., Miñarro J; Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universitat de València, Valencia 46010, Spain., Rodríguez-Arias M; Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universitat de València, Valencia 46010, Spain. Electronic address: marta.rodriguez@uv.es.
المصدر: Physiology & behavior [Physiol Behav] 2014 Jun 22; Vol. 133, pp. 152-60. Date of Electronic Publication: 2014 May 28.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 0151504 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-507X (Electronic) Linking ISSN: 00319384 NLM ISO Abbreviation: Physiol Behav Subsets: MEDLINE
أسماء مطبوعة: Publication: New York NY : Elsevier Science
Original Publication: Oxford, Eng., Long Island City, Pergamon Press.
مواضيع طبية MeSH: Reward*, Cocaine/*administration & dosage , Conditioning, Operant/*drug effects , Dopamine Uptake Inhibitors/*administration & dosage , Motor Activity/*drug effects, Age Factors ; Analysis of Variance ; Animals ; Exploratory Behavior/drug effects ; Female ; Linear Models ; Male ; Mice ; Reaction Time/drug effects
مستخلص: Novelty-seeking in rodents, defined as enhanced specific exploration of novel situations, is considered to predict the response of animals to drugs of abuse and, thus, allow "drug-vulnerable" individuals to be identified. The main objective of this study was to assess the predictive ability of two well-known paradigms of the novelty-seeking trait - novelty-induced locomotor activity (which distinguishes High- and Low-Responder mice, depending on their motor activity) and the hole-board test (which determines High- and Low-Novelty Seeker mice depending on the number of head dips they perform) - to identify subjects that would subsequently be more sensitive to the conditioned rewarding effects of cocaine in a population of young adult (PND 56) and adolescent (PND 35) OF1 mice of both sexes. Conditioned place preference (CPP), a useful tool for evaluating the sensitivity of individuals to the incentive properties of addictive drugs, was induced with a sub-threshold dose of cocaine (1 mg/kg, i.p.). Our results showed that novelty-induced motor activity had a greater predictive capacity to identify "vulnerable-drug" individuals among young-adult mice (PND 56), while the hole-board test was more effective in adolescents (PND 35). High-NR young-adults, which presented higher motor activity in the first ten minutes of the test (novelty-reactivity), were 3.9 times more likely to develop cocaine-induced CPP than Low-NR young-adults. When total activity (1h) was evaluated (novelty-habituation), only High-R (novelty-non-habituating) young-adult male and Low-R (novelty-habituating) female mice produced a high conditioning score. However, only High-Novelty Seeker male and female adolescents and Low-Novelty Seeker female young-adult animals (according to the hole-board test), acquired cocaine-induced CPP. These findings should contribute to the development of screening methods for identifying at-risk human drug users and prevention strategies for those with specific vulnerabilities.
(Copyright © 2014 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Adolescence; CPP; Cocaine; Mice; Novelty-induced activity; Novelty-seeking
المشرفين على المادة: 0 (Dopamine Uptake Inhibitors)
I5Y540LHVR (Cocaine)
تواريخ الأحداث: Date Created: 20140601 Date Completed: 20150219 Latest Revision: 20140627
رمز التحديث: 20221213
DOI: 10.1016/j.physbeh.2014.05.028
PMID: 24878312
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-507X
DOI:10.1016/j.physbeh.2014.05.028