دورية أكاديمية
أعرض في EDS

nNOS polymorphisms are associated with responsiveness to sildenafil in clinical and postoperative erectile dysfunction.

التفاصيل البيبلوغرافية
العنوان: nNOS polymorphisms are associated with responsiveness to sildenafil in clinical and postoperative erectile dysfunction.
المؤلفون: Lacchini R; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Av. Bandeirantes, 3900, 14049-900 Ribeirao Preto, SP, Brazil. tanus@fmrp.usp.br., Muniz JJ, Nobre YT, Cologna AJ, Martins AC, Tanus-Santos JE
المصدر: Pharmacogenomics [Pharmacogenomics] 2014 Apr; Vol. 15 (6), pp. 775-84.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Future Medicine Ltd Country of Publication: England NLM ID: 100897350 Publication Model: Print Cited Medium: Internet ISSN: 1744-8042 (Electronic) Linking ISSN: 14622416 NLM ISO Abbreviation: Pharmacogenomics Subsets: MEDLINE
أسماء مطبوعة: Publication: London : Future Medicine Ltd
Original Publication: London : Ashley Publications,
مواضيع طبية MeSH: Erectile Dysfunction/*drug therapy , Erectile Dysfunction/*genetics , Nitric Oxide Synthase Type I/*genetics , Piperazines/*therapeutic use , Polymorphism, Genetic/*genetics , Sulfones/*therapeutic use, Haplotypes ; Humans ; Male ; Middle Aged ; Postoperative Period ; Purines/therapeutic use ; Sildenafil Citrate
مستخلص: Aim: Sildenafil potentiates the nitric oxide (NO) signaling pathway. Since neuronal NOS is very important in the penis, we assessed whether NOS1 polymorphisms are associated with altered responsiveness to sildenafil in erectile dysfunction (ED).
Materials & Methods: Patients (n = 137) were divided as clinical ED or postoperative ED. They were subdivided as good responders or poor responders to sildenafil, and genotypes for rs41279104 and rs2682826 NOS1 polymorphisms were determined.
Results: We found that the rs41279104 CT genotype was associated with good responders in postoperative ED patients, while rs2682826 CT genotype was associated with good responders in postoperative ED, and the TT genotype associated with good responders in both groups. Finally, the CT haplotype was associated with good responders in postoperative ED.
Conclusion: NOS1 polymorphisms are associated with responsiveness to sildenafil in ED. Original submitted 20 November 2013; Revision submitted 31 January 2014.
فهرسة مساهمة: Keywords: NOS1; erectile dysfunction; nitric oxide; polymorphisms; prostatectomy; sildenafil
المشرفين على المادة: 0 (Piperazines)
0 (Purines)
0 (Sulfones)
BW9B0ZE037 (Sildenafil Citrate)
EC 1.14.13.39 (NOS1 protein, human)
EC 1.14.13.39 (Nitric Oxide Synthase Type I)
تواريخ الأحداث: Date Created: 20140605 Date Completed: 20150113 Latest Revision: 20151119
رمز التحديث: 20221213
DOI: 10.2217/pgs.14.30
PMID: 24897285
قاعدة البيانات: MEDLINE
الوصف
تدمد:1744-8042
DOI:10.2217/pgs.14.30