دورية أكاديمية

Lipid landscapes and pipelines in membrane homeostasis.

التفاصيل البيبلوغرافية
العنوان: Lipid landscapes and pipelines in membrane homeostasis.
المؤلفون: Holthuis JC; 1] Fachbereich Biologie/Chemie, University of Osnabrück, Barbarastrasse 13, 49076 Osnabrück, Germany. [2] Membrane Biochemistry & Biophysics, Bijvoet Center for Biomolecular Research and Institute of Biomembranes, Utrecht University, the Netherlands., Menon AK; Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.
المصدر: Nature [Nature] 2014 Jun 05; Vol. 510 (7503), pp. 48-57.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
أسماء مطبوعة: Publication: Basingstoke : Nature Publishing Group
Original Publication: London, Macmillan Journals ltd.
مواضيع طبية MeSH: Homeostasis*, Intracellular Membranes/*chemistry , Intracellular Membranes/*metabolism , Membrane Lipids/*chemistry , Membrane Lipids/*metabolism, Animals ; Carrier Proteins/metabolism ; Humans ; Lipid Bilayers/chemistry ; Lipid Bilayers/metabolism ; Membrane Lipids/analysis ; Membrane Lipids/biosynthesis ; Organelles/chemistry ; Organelles/metabolism ; Sphingolipids/metabolism
مستخلص: The lipid composition of cellular organelles is tailored to suit their specialized tasks. A fundamental transition in the lipid landscape divides the secretory pathway in early and late membrane territories, allowing an adaptation from biogenic to barrier functions. Defending the contrasting features of these territories against erosion by vesicular traffic poses a major logistical problem. To this end, cells evolved a network of lipid composition sensors and pipelines along which lipids are moved by non-vesicular mechanisms. We review recent insights into the molecular basis of this regulatory network and consider examples in which malfunction of its components leads to system failure and disease.
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معلومات مُعتمدة: R01 GM071041 United States GM NIGMS NIH HHS; GM071041 United States GM NIGMS NIH HHS
المشرفين على المادة: 0 (Carrier Proteins)
0 (Lipid Bilayers)
0 (Membrane Lipids)
0 (Sphingolipids)
0 (lipid transfer protein)
تواريخ الأحداث: Date Created: 20140606 Date Completed: 20140710 Latest Revision: 20211021
رمز التحديث: 20240628
DOI: 10.1038/nature13474
PMID: 24899304
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-4687
DOI:10.1038/nature13474