دورية أكاديمية
أعرض في EDS

The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.

التفاصيل البيبلوغرافية
العنوان: The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.
المؤلفون: Sato H; Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan; Department of Health Chemistry, Showa University, School of Pharmacy, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan., Taketomi Y; Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan; Department of Health Chemistry, Showa University, School of Pharmacy, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan., Ushida A; Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan; Department of Biology, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan., Isogai Y; Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan; Department of Biology, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan., Kojima T; Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan., Hirabayashi T; Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan., Miki Y; Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan; Department of Health Chemistry, Showa University, School of Pharmacy, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan., Yamamoto K; Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan., Nishito Y; Core Technology and Research Center, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan., Kobayashi T; Department of Biology, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan., Ikeda K; Institute for Advanced Biosciences, Keio University, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata 997-0052, Japan., Taguchi R; Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai-shi, Aichi 487-8501, Japan., Hara S; Department of Health Chemistry, Showa University, School of Pharmacy, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan., Ida S; Department of Gastroenterological Surgery, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan., Miyamoto Y; Department of Gastroenterological Surgery, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan., Watanabe M; Department of Gastroenterological Surgery, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan., Baba H; Department of Gastroenterological Surgery, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan., Miyata K; Department of Molecular Genetics, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan., Oike Y; Department of Molecular Genetics, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan., Gelb MH; Departments of Chemistry and Biochemistry, University of Washington, Campus Box 351700, 36 Bagley Hall, Seattle, WA 98195, USA., Murakami M; Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan; CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan. Electronic address: murakami-mk@igakuken.or.jp.
المصدر: Cell metabolism [Cell Metab] 2014 Jul 01; Vol. 20 (1), pp. 119-32. Date of Electronic Publication: 2014 Jun 05.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, Mass. : Cell Press, c2005-
مواضيع طبية MeSH: Adipose Tissue, White/*metabolism , Group II Phospholipases A2/*metabolism , Group V Phospholipases A2/*metabolism , Obesity/*etiology, Adipose Tissue, White/cytology ; Animals ; Cells, Cultured ; Diet, High-Fat ; Female ; Glucose Tolerance Test ; Group II Phospholipases A2/deficiency ; Group II Phospholipases A2/genetics ; Group V Phospholipases A2/deficiency ; Group V Phospholipases A2/genetics ; Humans ; Inflammation/metabolism ; Inflammation/pathology ; Insulin/blood ; Leptin/blood ; Leptin/metabolism ; Lipoproteins/metabolism ; Liver/pathology ; Macrophages/cytology ; Macrophages/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Obese ; Obesity/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; RNA, Messenger/metabolism ; Time Factors
مستخلص: Metabolic disorders, including obesity and insulin resistance, have their basis in dysregulated lipid metabolism and low-grade inflammation. In a microarray search of unique lipase-related genes whose expressions are associated with obesity, we found that two secreted phospholipase A2s (sPLA2s), PLA2G5 and PLA2G2E, were robustly induced in adipocytes of obese mice. Analyses of Pla2g5(-/-) and Pla2g2e(-/-) mice revealed distinct roles of these sPLA2s in diet-induced obesity. PLA2G5 hydrolyzed phosphatidylcholine in fat-overladen low-density lipoprotein to release unsaturated fatty acids, which prevented palmitate-induced M1 macrophage polarization. As such, PLA2G5 tipped the immune balance toward an M2 state, thereby counteracting adipose tissue inflammation, insulin resistance, hyperlipidemia, and obesity. PLA2G2E altered minor lipoprotein phospholipids, phosphatidylserine and phosphatidylethanolamine, and moderately facilitated lipid accumulation in adipose tissue and liver. Collectively, the identification of "metabolic sPLA2s" adds this gene family to a growing list of lipolytic enzymes that act as metabolic coordinators.
(Copyright © 2014 Elsevier Inc. All rights reserved.)
References: Endocrinology. 2010 Mar;151(3):993-1001. (PMID: 20056822)
Nat Genet. 2010 Jan;42(1):21-3. (PMID: 19946271)
Nature. 2008 Mar 27;452(7186):429-35. (PMID: 18344982)
Prog Lipid Res. 2011 Apr;50(2):152-92. (PMID: 21185866)
Arterioscler Thromb Vasc Biol. 2013 Mar;33(3):466-73. (PMID: 23349189)
Biochim Biophys Acta. 2005 Sep 5;1736(1):38-50. (PMID: 16122976)
J Immunol. 2009 Apr 15;182(8):4891-8. (PMID: 19342668)
Diabetes. 2012 Sep;61(9):2320-9. (PMID: 22923652)
EMBO Mol Med. 2010 May;2(5):172-87. (PMID: 20432503)
J Intern Med. 2008 Aug;264(2):155-65. (PMID: 18298481)
J Clin Invest. 2010 May;120(5):1400-14. (PMID: 20424323)
PLoS One. 2013;8(2):e56172. (PMID: 23451035)
J Biol Chem. 2000 Feb 25;275(8):5785-93. (PMID: 10681567)
Biochem Cell Biol. 2007 Dec;85(6):696-708. (PMID: 18059528)
Nature. 2006 Dec 14;444(7121):860-7. (PMID: 17167474)
Bioorg Med Chem Lett. 2005 Jun 2;15(11):2781-5. (PMID: 15911255)
Biochem Biophys Res Commun. 2007 Mar 16;354(3):820-4. (PMID: 17258176)
Hum Mol Genet. 2007 Jun 15;16(12):1437-44. (PMID: 17545304)
J Immunol. 2009 Apr 1;182(7):4415-22. (PMID: 19299742)
J Biol Chem. 2006 Nov 24;281(47):36420-33. (PMID: 17008322)
J Immunol. 2011 Nov 15;187(10):5408-18. (PMID: 22013115)
Circ Res. 2006 Mar 3;98(4):490-8. (PMID: 16439686)
Cell. 1995 Jun 16;81(6):957-66. (PMID: 7781071)
Science. 2006 Aug 25;313(5790):1137-40. (PMID: 16931765)
Nature. 2006 Dec 14;444(7121):881-7. (PMID: 17167477)
J Lipid Res. 2005 Nov;46(11):2347-55. (PMID: 16150820)
Circ Res. 2010 Sep 3;107(5):650-8. (PMID: 20634488)
Am J Hum Genet. 2011 Dec 9;89(6):782-91. (PMID: 22137173)
Science. 2006 May 5;312(5774):734-7. (PMID: 16675698)
J Immunol. 2011 Aug 1;187(3):1157-65. (PMID: 21709158)
Cell Metab. 2011 Jan 5;13(1):105-13. (PMID: 21195353)
J Immunol. 2010 Oct 1;185(7):4430-8. (PMID: 20817863)
J Biol Chem. 2004 May 21;279(21):21740-8. (PMID: 15024020)
J Biol Chem. 2008 Nov 28;283(48):33483-97. (PMID: 18801741)
Immunity. 2013 Apr 18;38(4):644-54. (PMID: 23601683)
J Exp Med. 2013 Jun 3;210(6):1217-34. (PMID: 23690440)
Nat Med. 2009 Feb;15(2):159-68. (PMID: 19136964)
Science. 1995 Jul 28;269(5223):540-3. (PMID: 7624776)
Cell Metab. 2014 Jan 7;19(1):21-36. (PMID: 24239568)
Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):600-6. (PMID: 17204667)
Nat Immunol. 2013 Jun;14(6):554-63. (PMID: 23624557)
Cell Metab. 2012 May 2;15(5):564-5. (PMID: 22560206)
Circulation. 2010 Jan 26;121(3):426-35. (PMID: 20065164)
J Biol Chem. 2004 Apr 16;279(16):16488-94. (PMID: 14761945)
J Biol Chem. 1999 Oct 29;274(44):31195-202. (PMID: 10531313)
Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):313-20. (PMID: 19948841)
Arterioscler Thromb Vasc Biol. 1999 May;19(5):1284-90. (PMID: 10323781)
معلومات مُعتمدة: R01 HL036235 United States HL NHLBI NIH HHS; R37 HL036235 United States HL NHLBI NIH HHS; HL36235 United States HL NHLBI NIH HHS
المشرفين على المادة: 0 (Insulin)
0 (Leptin)
0 (Lipoproteins)
0 (RNA, Messenger)
EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
EC 3.1.1.4 (Group II Phospholipases A2)
EC 3.1.1.4 (Group V Phospholipases A2)
EC 3.1.1.4 (Pla2g2e protein, mouse)
EC 3.1.1.4 (Pla2g5 protein, mouse)
تواريخ الأحداث: Date Created: 20140610 Date Completed: 20150212 Latest Revision: 20220321
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4079757
DOI: 10.1016/j.cmet.2014.05.002
PMID: 24910243
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-7420
DOI:10.1016/j.cmet.2014.05.002