دورية أكاديمية
GABA derivatives citrocard and salifen reduce the intensity of experimental gestosis.
| العنوان: | GABA derivatives citrocard and salifen reduce the intensity of experimental gestosis. |
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| المؤلفون: | Tyurenkov IN; Department of Pharmacology and Biopharmacy, College for Advanced Medical Studies; Laboratory of Pharmacological Kinetics, Volgograd State Medical University, Volgograd, Russia., Lova VN, Reznikova LB, Smirnova LA, Ryabukha AF, Suchkov EA, Kuznetsov KA |
| المصدر: | Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2014 May; Vol. 157 (1), pp. 42-4. Date of Electronic Publication: 2014 Jun 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Springer Original Publication: New York, Consultants Bureau. |
| مواضيع طبية MeSH: | GABA Agonists/*pharmacology , Pre-Eclampsia/*drug therapy , gamma-Aminobutyric Acid/*analogs & derivatives, Animals ; Blood Pressure/drug effects ; Brain/drug effects ; Brain/metabolism ; Brain/pathology ; Female ; Glycosaminoglycans/pharmacology ; Homocysteine/blood ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Omentum/drug effects ; Omentum/metabolism ; Omentum/pathology ; Pre-Eclampsia/blood ; Pre-Eclampsia/chemically induced ; Pre-Eclampsia/pathology ; Pregnancy ; Rats ; Sodium Chloride ; gamma-Aminobutyric Acid/pharmacology |
| مستخلص: | Substitution of drinking water with 1.8 % NaCl solution in pregnant female rats from day 1 of gestation until parturitions was followed by the development of experimental gestosis. Gestosis manifested in an increase in BP by 18.2 %, protein concentration in the urine by 6.2 times, and edema severity in muscles, brain, and omentum in comparison with the initial level. The concentration of homocysteine in blood plasma of rats with complicated pregnancy 4.4-fold surpassed that in pregnant rats without gestosis, which can probably in a cause for gestosis development. GABA derivatives citrocard (50 mg/kg) and salifen (15 mg/kg), and the reference substance sulodexide (30 U/kg) reduced the severity of gestosis manifestations, which was seen from the absence of BP rise, decrease in urinary protein concentration by 1.9, 2.0, and 1.3 times and blood level of homocysteine by 1.7, 1.5, and 2.6 times, respectively, and a decrease in edema degree in comparison with female rats with experimental gestosis receiving physiological saline. |
| المشرفين على المادة: | 0 (GABA Agonists) 0 (Glycosaminoglycans) 0LVT1QZ0BA (Homocysteine) 451W47IQ8X (Sodium Chloride) 56-12-2 (gamma-Aminobutyric Acid) 75HGV0062C (glucuronyl glucosamine glycan sulfate) T2M58D6LA8 (4-amino-3-phenylbutyric acid) |
| تواريخ الأحداث: | Date Created: 20140611 Date Completed: 20150219 Latest Revision: 20161125 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1007/s10517-014-2487-z |
| PMID: | 24913573 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1573-8221 |
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| DOI: | 10.1007/s10517-014-2487-z |