دورية أكاديمية
Galectin-8: a matricellular lectin with key roles in angiogenesis.
| العنوان: | Galectin-8: a matricellular lectin with key roles in angiogenesis. |
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| المؤلفون: | Troncoso MF; Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro Paladini (UBA-CONICET), Facultad de Farmacia y Bioquímica., Ferragut F; Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro Paladini (UBA-CONICET), Facultad de Farmacia y Bioquímica., Bacigalupo ML; Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro Paladini (UBA-CONICET), Facultad de Farmacia y Bioquímica., Cárdenas Delgado VM; Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro Paladini (UBA-CONICET), Facultad de Farmacia y Bioquímica., Nugnes LG; Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro Paladini (UBA-CONICET), Facultad de Farmacia y Bioquímica., Gentilini L; Laboratorio de Glicómica Funcional, IQUIBICEN-CONICET, Departamento de Química Biológica. Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina., Laderach D; Laboratorio de Glicómica Funcional, IQUIBICEN-CONICET, Departamento de Química Biológica. Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina., Wolfenstein-Todel C; Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro Paladini (UBA-CONICET), Facultad de Farmacia y Bioquímica., Compagno D; Laboratorio de Glicómica Funcional, IQUIBICEN-CONICET, Departamento de Química Biológica. Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina., Rabinovich GA; Laboratorio de Glicómica Funcional, IQUIBICEN-CONICET, Departamento de Química Biológica. Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME - CONICET), Buenos Aires, Argentina., Elola MT; Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro Paladini (UBA-CONICET), Facultad de Farmacia y Bioquímica mtelola@gmail.com. |
| المصدر: | Glycobiology [Glycobiology] 2014 Oct; Vol. 24 (10), pp. 907-14. Date of Electronic Publication: 2014 Jun 16. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9104124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2423 (Electronic) Linking ISSN: 09596658 NLM ISO Abbreviation: Glycobiology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford ; New York : IRL Press at Oxford University Press, c1990- |
| مواضيع طبية MeSH: | Carcinogenesis/*genetics , Galectins/*genetics , Neoplasms/*genetics , Neovascularization, Pathologic/*genetics, Antigens, CD/genetics ; Antigens, CD/metabolism ; Cell Adhesion/genetics ; Cell Adhesion Molecules, Neuronal/genetics ; Cell Adhesion Molecules, Neuronal/metabolism ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Extracellular Matrix/genetics ; Fetal Proteins/genetics ; Fetal Proteins/metabolism ; Galectins/metabolism ; Humans ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Neoplasm Metastasis ; Neoplasms/pathology ; Neovascularization, Pathologic/pathology |
| مستخلص: | Galectin-8 (gal-8) is a "tandem-repeat"-type galectin, containing two carbohydrate recognition domains connected by a linker peptide. gal-8 is expressed both in the cytoplasm and nucleus in vascular endothelial cells (ECs) from normal and tumor-associated blood vessels, and in lymphatic endothelial cells. Herein, we describe a novel role for gal-8 in the regulation of vascular and lymphatic angiogenesis and provide evidence of its critical implications in tumor biology. Functional assays revealed central roles for gal-8 in the control of capillary-tube formation, EC migration and in vivo angiogenesis. So far, two endothelial ligands have been described for gal-8, namely podoplanin in lymphatic vessels and CD166 (ALCAM, activated leukocyte cell adhesion molecule) in vascular ECs. Other related gal-8 functions are also summarized here, including cell adhesion and migration, which collectively demonstrate the multi-functionality of this complex lectin. Thus, gal-8 is an important component of the angiogenesis network, and an essential molecule in the extracellular matrix by providing molecular anchoring to this surrounding matrix. The implications of gal-8 in tumor angiogenesis remain to be further explored, but it is exciting to speculate that modulating gal-8-glycan interactions could be used to block lymphatic-vascular connections vital for metastasis. (© The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: CD166; angiogenesis; endothelium; galectin-8 |
| المشرفين على المادة: | 0 (ALCAM protein, human) 0 (Antigens, CD) 0 (Cell Adhesion Molecules, Neuronal) 0 (Fetal Proteins) 0 (Galectins) 0 (LGALS8 protein, human) 0 (Membrane Glycoproteins) 0 (PDPN protein, human) |
| تواريخ الأحداث: | Date Created: 20140619 Date Completed: 20150514 Latest Revision: 20140904 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1093/glycob/cwu054 |
| PMID: | 24939370 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1460-2423 |
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| DOI: | 10.1093/glycob/cwu054 |