دورية أكاديمية
Seroprevalence of IgG antibodies to herpes simplex virus type-1 in Nigerian children.
| العنوان: | Seroprevalence of IgG antibodies to herpes simplex virus type-1 in Nigerian children. |
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| المؤلفون: | Shaibu AM, Aminu M, Musa BO, Bugaje MA |
| المصدر: | Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria [Niger J Med] 2014 Jan-Mar; Vol. 23 (1), pp. 40-5. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: The Association Country of Publication: Nigeria NLM ID: 100888321 Publication Model: Print Cited Medium: Print ISSN: 1115-2613 (Print) Linking ISSN: 11152613 NLM ISO Abbreviation: Niger J Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lagos, Nigeria] : The Association, |
| مواضيع طبية MeSH: | Antibodies, Viral/*blood , Herpes Simplex/*immunology , Herpesvirus 1, Human/*immunology , Immunoglobulin G/*blood, Child, Preschool ; Cross-Sectional Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Herpes Simplex/epidemiology ; Humans ; Infant ; Infant, Newborn ; Male ; Nigeria/epidemiology ; Prevalence ; Risk Factors ; Seroepidemiologic Studies |
| مستخلص: | Background: Herpes simplex virus type-1 (HSV-1) can cause chronic ulcerative infection in immunosuppressed children leading to latency with subsequent reactivate in the conjunctiva resulting in scarring, thickening of the cornea and blindness. They are also common cause of fatal sporadic encephalitis in 70% of paediatric patients. This cross sectional study determined the prevalence of HSV-1 in children in Kaduna State, Nigeria. Method: A total of 377 blood samples were collected from children less than five years old attending some selected hospitals in Kaduna State and analyzed for HSV-1 IgG antibodies employing Enzyme immune assaytechnique by using commercially available ELISA Kits. Results: Sero-prevalence rate of 57.8% (218/377) was obtained. The highest prevalence of HSV-1 infection was obtained in children in age group 49-60 months (85.2%) and lowest in children in age group 13-24 months (44.8%). Further analysis of the result of children less than one year old showed that children 9-16 weeks old were more susceptible to HSV-1 infection. HSV-1 infection was significantly associated with age (X2 = 37.92, df = 4, p = 0.001). Though a higher prevalence was obtained in female children (61.5%) than male children (54.5%), the difference observed in the prevalence was not statistically significant (X2 = 1.84, df = 1, P = 0.105). HSV-1 infection was significantly associated with children who were in school (X2 = 15.28, df = 1, P = 0.001) with a higher prevalence of 74.3%. Conclusion: Over half of the children sampled were protected from HSV-1 infection while 42.2% were susceptible to the infection and were at risk of developing severe HSV-1 manifestation which includes keratitis, encephalitis and Keratoconjunctivitis. |
| المشرفين على المادة: | 0 (Antibodies, Viral) 0 (Immunoglobulin G) |
| تواريخ الأحداث: | Date Created: 20140621 Date Completed: 20140710 Latest Revision: 20220410 |
| رمز التحديث: | 20240628 |
| PMID: | 24946453 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1115-2613 |
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