دورية أكاديمية
The effect of multiple micronutrient supplementation on left ventricular ejection fraction in patients with chronic stable heart failure: a randomized, placebo-controlled trial.
| العنوان: | The effect of multiple micronutrient supplementation on left ventricular ejection fraction in patients with chronic stable heart failure: a randomized, placebo-controlled trial. |
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| المؤلفون: | McKeag NA; Centre for Public Health, School of Medicine, Dentistry & Biomedical Sciences, Queen's University, Belfast, Northern Ireland; The Heart Centre, Belfast Health & Social Care Trust, Belfast, Northern Ireland. Electronic address: nickmckeag@googlemail.com., McKinley MC; Centre for Public Health, School of Medicine, Dentistry & Biomedical Sciences, Queen's University, Belfast, Northern Ireland., Harbinson MT; The Heart Centre, Belfast Health & Social Care Trust, Belfast, Northern Ireland; Centre for Medical Education, School of Medicine, Dentistry & Biomedical Sciences, Queen's University, Belfast, Northern Ireland., Noad RL; Centre for Public Health, School of Medicine, Dentistry & Biomedical Sciences, Queen's University, Belfast, Northern Ireland; The Heart Centre, Belfast Health & Social Care Trust, Belfast, Northern Ireland., Dixon LH; The Heart Centre, Belfast Health & Social Care Trust, Belfast, Northern Ireland., McGinty A; Centre for Public Health, School of Medicine, Dentistry & Biomedical Sciences, Queen's University, Belfast, Northern Ireland., Neville CE; Centre for Public Health, School of Medicine, Dentistry & Biomedical Sciences, Queen's University, Belfast, Northern Ireland., Woodside JV; Centre for Public Health, School of Medicine, Dentistry & Biomedical Sciences, Queen's University, Belfast, Northern Ireland., McKeown PP; The Heart Centre, Belfast Health & Social Care Trust, Belfast, Northern Ireland; Centre for Medical Education, School of Medicine, Dentistry & Biomedical Sciences, Queen's University, Belfast, Northern Ireland. |
| المصدر: | JACC. Heart failure [JACC Heart Fail] 2014 Jun; Vol. 2 (3), pp. 308-17. |
| نوع المنشور: | Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101598241 Publication Model: Print Cited Medium: Internet ISSN: 2213-1787 (Electronic) Linking ISSN: 22131779 NLM ISO Abbreviation: JACC Heart Fail Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Elsevier, [2013]- |
| مواضيع طبية MeSH: | Heart Failure/*diet therapy , Micronutrients/*administration & dosage , Stroke Volume/*physiology, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Chronic Disease ; Dietary Supplements ; Double-Blind Method ; Echocardiography/methods ; Exercise Test ; Exercise Tolerance/physiology ; Female ; Heart Failure/physiopathology ; Humans ; Magnetic Resonance Angiography/methods ; Male ; Medication Adherence ; Middle Aged ; Treatment Outcome ; Young Adult |
| مستخلص: | Objectives: This study sought to investigate the effect of a multiple micronutrient supplement on left ventricular ejection fraction (LVEF) in patients with heart failure. Background: Observational studies suggest that patients with heart failure have reduced intake and lower concentrations of a number of micronutrients. However, there have been very few intervention studies investigating the effect of micronutrient supplementation in patients with heart failure. Methods: This was a randomized, double-blind, placebo-controlled, parallel-group study involving 74 patients with chronic stable heart failure that compared multiple micronutrient supplementation taken once daily versus placebo for 12 months. The primary endpoint was LVEF assessed by cardiovascular magnetic resonance imaging or 3-dimensional echocardiography. Secondary endpoints were Minnesota Living With Heart Failure Questionnaire score, 6-min walk test distance, blood concentrations of N-terminal prohormone of brain natriuretic peptide, C-reactive protein, tumor necrosis factor alpha, interleukin-6, interleukin-10, and urinary levels of 8-iso-prostaglandin F2 alpha. Results: Blood concentrations of a number of micronutrients increased significantly in the micronutrient supplement group, indicating excellent compliance with the intervention. There was no significant difference in mean LVEF at 12 months between treatment groups after adjusting for baseline (mean difference: 1.6%, 95% confidence interval: -2.6 to 5.8, p = 0.441). There was also no significant difference in any of the secondary endpoints at 12 months between treatment groups. Conclusions: This study provides no evidence to support the routine treatment of patients with chronic stable heart failure with a multiple micronutrient supplement. (Micronutrient Supplementation in Patients With Heart Failure [MINT-HF]; NCT01005303). (Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.) |
| التعليقات: | Erratum in: JACC Heart Fail. 2014 Oct;2(5):549. Comment in: JACC Heart Fail. 2014 Jun;2(3):318-20. (PMID: 24952701) |
| معلومات مُعتمدة: | MR/K023241/1 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: heart failure; micronutrient; nutrition |
| سلسلة جزيئية: | ClinicalTrials.gov NCT01005303 |
| المشرفين على المادة: | 0 (Micronutrients) |
| تواريخ الأحداث: | Date Created: 20140623 Date Completed: 20150202 Latest Revision: 20220129 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.jchf.2013.12.008 |
| PMID: | 24952700 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2213-1787 |
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| DOI: | 10.1016/j.jchf.2013.12.008 |