دورية أكاديمية

Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease.

التفاصيل البيبلوغرافية
العنوان: Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease.
المؤلفون: Fitzsimons CP; Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, SciencePark 904, 1098XH Amsterdam, The Netherlands. C.P.Fitzsimons@uva.nl., van Bodegraven E, Schouten M, Lardenoije R, Kompotis K, Kenis G, van den Hurk M, Boks MP, Biojone C, Joca S, Steinbusch HW, Lunnon K, Mastroeni DF, Mill J, Lucassen PJ, Coleman PD, van den Hove DL, Rutten BP
المصدر: Molecular neurodegeneration [Mol Neurodegener] 2014 Jun 25; Vol. 9, pp. 25. Date of Electronic Publication: 2014 Jun 25.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2006-
مواضيع طبية MeSH: Adult Stem Cells* , Alzheimer Disease* , Epigenesis, Genetic* , Neural Stem Cells* , Neurogenesis*, Aging ; Animals ; Humans
مستخلص: Experimental evidence has demonstrated that several aspects of adult neural stem cells (NSCs), including their quiescence, proliferation, fate specification and differentiation, are regulated by epigenetic mechanisms. These control the expression of specific sets of genes, often including those encoding for small non-coding RNAs, indicating a complex interplay between various epigenetic factors and cellular functions.Previous studies had indicated that in addition to the neuropathology in Alzheimer's disease (AD), plasticity-related changes are observed in brain areas with ongoing neurogenesis, like the hippocampus and subventricular zone. Given the role of stem cells e.g. in hippocampal functions like cognition, and given their potential for brain repair, we here review the epigenetic mechanisms relevant for NSCs and AD etiology. Understanding the molecular mechanisms involved in the epigenetic regulation of adult NSCs will advance our knowledge on the role of adult neurogenesis in degeneration and possibly regeneration in the AD brain.
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تواريخ الأحداث: Date Created: 20140627 Date Completed: 20140912 Latest Revision: 20231110
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4080757
DOI: 10.1186/1750-1326-9-25
PMID: 24964731
قاعدة البيانات: MEDLINE
الوصف
تدمد:1750-1326
DOI:10.1186/1750-1326-9-25