دورية أكاديمية
Plasmid-mediated qnrA1 in Klebsiella pneumoniae ST147 in Recife, Brazil.
| العنوان: | Plasmid-mediated qnrA1 in Klebsiella pneumoniae ST147 in Recife, Brazil. |
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| المؤلفون: | Rocha LK; Laboratório de Resistência Microbiana, Instituto de Ciências Biológicas, Universidade de Pernambuco, Recife, Brasil., dos Santos Neto RL; Laboratório de Resistência Microbiana, Instituto de Ciências Biológicas, Universidade de Pernambuco, Recife, Brasil., da Costa Guimarães AC; Laboratório de Resistência Microbiana, Instituto de Ciências Biológicas, Universidade de Pernambuco, Recife, Brasil., Almeida AC; Laboratório de Resistência Microbiana, Instituto de Ciências Biológicas, Universidade de Pernambuco, Recife, Brasil; Departamento de Genética, Universidade Federal de Pernambuco, Recife, Brasil; Departamento de Biologia, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, s/n, Dois Irmãos, CEP: 52171-900, Recife, Brasil. Electronic address: annacalmeida@hotmail.com., Vilela MA; Laboratório de Resistência Microbiana, Instituto de Ciências Biológicas, Universidade de Pernambuco, Recife, Brasil., de Morais MM; Laboratório de Resistência Microbiana, Instituto de Ciências Biológicas, Universidade de Pernambuco, Recife, Brasil. |
| المصدر: | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2014 Sep; Vol. 26, pp. 49-50. Date of Electronic Publication: 2014 Jun 26. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Canada NLM ID: 9610933 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3511 (Electronic) Linking ISSN: 12019712 NLM ISO Abbreviation: Int J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hamilton, ON : Elsevier Original Publication: Hamilton, ON : Decker, c1996- |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*pharmacology , Ciprofloxacin/*pharmacology , Klebsiella pneumoniae/*drug effects , Klebsiella pneumoniae/*genetics , Plasmids/*genetics, Adult ; Brazil ; Drug Resistance, Microbial/genetics ; Female ; Genes, Bacterial ; Humans ; Integrons ; Klebsiella pneumoniae/isolation & purification |
| مستخلص: | Objectives: Qnr-mediated quinolone resistance is increasingly detected worldwide, but few studies have been carried out so far in Brazil. The aim of this study was to test for qnr determinants in isolates of ciprofloxacin-resistant Klebsiella pneumoniae. Methods: Fifteen ciprofloxacin-resistant isolates from urine cultures of hospitalized patients at a university hospital in North-East Brazil were investigated. Specific PCRs were performed for blaCTX-M and blaTEM, qnr, and class 1 integrons. Plasmid analyses and sequence type (ST) determination were performed, as described previously. Results: The KP 930 isolate showed qnrA1 and blaTEM-1, together with dfrA12 and aadA2 in a class 1 integron. The qnr gene was located in a 133-kb plasmid. Multilocus sequence typing classified the isolate as ST147. Conclusions: We identified the combination of qnr with ST147 in Brazil; this is a clone that has disseminated widely and successfully in Latin America. The purpose of describing Qnr-mediated quinolone resistance in North-East Brazil is to draw attention to the spread of this mechanism in the country. (Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Quinolones; Resistance; qnrA1 |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 5E8K9I0O4U (Ciprofloxacin) |
| تواريخ الأحداث: | Date Created: 20140702 Date Completed: 20151102 Latest Revision: 20201209 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.ijid.2014.04.026 |
| PMID: | 24980465 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1878-3511 |
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| DOI: | 10.1016/j.ijid.2014.04.026 |