دورية أكاديمية
Biotransformation of 20(R)-panaxadiol by the fungus Rhizopus chinensis.
| العنوان: | Biotransformation of 20(R)-panaxadiol by the fungus Rhizopus chinensis. |
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| المؤلفون: | Lin XH; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China., Cao MN; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China., He WN; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China., Yu SW; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China. Electronic address: swang_yu@bjmu.edu.cn., Guo DA; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China., Ye M; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China. Electronic address: yemin@bjmu.edu.cn. |
| المصدر: | Phytochemistry [Phytochemistry] 2014 Sep; Vol. 105, pp. 129-34. Date of Electronic Publication: 2014 Jun 30. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3700 (Electronic) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : London : Elsevier Original Publication: 1961-2003: Oxford : Pergamon Press. |
| مواضيع طبية MeSH: | Antineoplastic Agents/*pharmacology , Ginsenosides/*pharmacology , Rhizopus/*metabolism, Antineoplastic Agents/chemistry ; Biotransformation ; Colonic Neoplasms/drug therapy ; Drug Screening Assays, Antitumor ; Fungi/metabolism ; Humans ; Hydroxylation ; Lipopolysaccharides/pharmacology ; Luciferases/metabolism ; Molecular Structure ; NF-kappa B/metabolism ; Nuclear Magnetic Resonance, Biomolecular ; Stereoisomerism |
| مستخلص: | Microbial transformation of 20(R)-panaxadiol by the fungus Rhizopus chinensis CICC 3043 yielded seven metabolites. Their structures were elucidated on the basis of extensive spectroscopic analyses. R. chinensis could catalyze hydroxylation and further dehydrogenation at C-24 of 20(R)-panaxadiol, as well as hydroxylation at C-7, C-15, C-16, and C-29. Three of these compounds at 10μM could moderately inhibit growth of HepG2 human hepatocellular carcinoma cells with an inhibition rate of about 40%. Three compounds (also at 10μM) showed approximately 30% inhibition on NF-κB transcriptional activity in SW480 human colon carcinoma cells stably transfected with NF-κB luciferase reporter and induced by LPS. (Copyright © 2014 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: 20(R)-Panaxadiol; Araliaceae; Biotransformation; Ginseng; HepG2; NF-κB; Panax ginseng; Rhizopus chinensis |
| المشرفين على المادة: | 0 (Antineoplastic Agents) 0 (Ginsenosides) 0 (Lipopolysaccharides) 0 (NF-kappa B) 19666-76-3 (panaxadiol) EC 1.13.12.- (Luciferases) |
| تواريخ الأحداث: | Date Created: 20140705 Date Completed: 20150204 Latest Revision: 20140804 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.phytochem.2014.06.001 |
| PMID: | 24994672 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3700 |
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| DOI: | 10.1016/j.phytochem.2014.06.001 |