دورية أكاديمية
أعرض في EDS

Thermal and pH Sensitive Multifunctional Polymer Nanoparticles for Cancer Imaging and Therapy.

التفاصيل البيبلوغرافية
العنوان: Thermal and pH Sensitive Multifunctional Polymer Nanoparticles for Cancer Imaging and Therapy.
المؤلفون: Lei T; Biomedical Engineering Department, Florida International University, 10555 West Flagler Street, Miami, FL 33174, USA ; Cirle, 1951 NW 7 Ave, Suite 13106, Miami, FL, 33136., Manchanda R; Biomedical Engineering Department, Florida International University, 10555 West Flagler Street, Miami, FL 33174, USA ; Department of Basic and Applied Sciences. Galgotias University, UP, 201308, India., Fernandez-Fernandez A; Biomedical Engineering Department, Florida International University, 10555 West Flagler Street, Miami, FL 33174, USA ; Physical Therapy Department, Nova Southeastern University, 3200 S. University Dr., Fort Lauderdale, FL 33328, USA., Huang YC; Biomedical Engineering Department, Florida International University, 10555 West Flagler Street, Miami, FL 33174, USA., Wright D; Biomedical Engineering Department, Florida International University, 10555 West Flagler Street, Miami, FL 33174, USA., McGoron AJ; Biomedical Engineering Department, Florida International University, 10555 West Flagler Street, Miami, FL 33174, USA.
المصدر: RSC advances [RSC Adv] 2014 Jan 01; Vol. 4 (34), pp. 17959-17968.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101581657 Publication Model: Print Cited Medium: Print ISSN: 2046-2069 (Print) Linking ISSN: 20462069 NLM ISO Abbreviation: RSC Adv Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Cambridge [England] : Royal Society of Chemistry, [2011]-
مستخلص: In this study, we prepared novel poly(Glycerol malate co-dodecanedioate) (PGMD) NPs containing an imaging/hyperthermia agent (IR820) and a chemotherapeutic agent (doxorubicin, DOX). The PGMD polymer was prepared by thermal condensation. IR820 and DOX loaded PGMD NPs were prepared using the single oil emulsion technique. The size of the NPs measured was around 150 nm. Drug loading efficiency of DOX and IR820 was around 4% and 8%, respectively. An acidic environment (pH=5.0) induced higher DOX release as compared to pH=7.4. DOX release was also enhanced by exposure to laser, which increased the temperature to 42°C. Cytotoxicity of the drug loaded NPs was comparable in MES-SA but was higher in Dx5 cells compared to free drug (p<0.05). The combination of hyperthermia and chemotherapy improved cytotoxicity in both cell lines. The NP formulation significantly improved the plasma half-life of IR820 in mice after tail vein injection.
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معلومات مُعتمدة: R15 CA167571 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: IR820; chemotherapy; hyperthermia; multifunctional nanoparticles; poly(Glycerol malate co-dodecanedioate) (PGMD)
تواريخ الأحداث: Date Created: 20140708 Latest Revision: 20211021
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4078889
DOI: 10.1039/C4RA01112K
PMID: 24999382
قاعدة البيانات: MEDLINE
الوصف
تدمد:2046-2069
DOI:10.1039/C4RA01112K