دورية أكاديمية
أعرض في EDS

Platelet-lymphocyte ratio is an independent predictor for cardiovascular disease in obstructive sleep apnea syndrome.

التفاصيل البيبلوغرافية
العنوان: Platelet-lymphocyte ratio is an independent predictor for cardiovascular disease in obstructive sleep apnea syndrome.
المؤلفون: Koseoglu HI; Gaziosmanpasa University Faculty of Medicine, Tokat, Turkey, handaninonu@gmail.com., Altunkas F, Kanbay A, Doruk S, Etikan I, Demir O
المصدر: Journal of thrombosis and thrombolysis [J Thromb Thrombolysis] 2015 Feb; Vol. 39 (2), pp. 179-85.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 9502018 Publication Model: Print Cited Medium: Internet ISSN: 1573-742X (Electronic) Linking ISSN: 09295305 NLM ISO Abbreviation: J Thromb Thrombolysis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Dordrecht ; Norwell, MA] : Kluwer Academic Publishers, c1994-
مواضيع طبية MeSH: Cardiovascular Diseases*/blood , Cardiovascular Diseases*/etiology , Cardiovascular Diseases*/physiopathology , Sleep Apnea, Obstructive*/blood , Sleep Apnea, Obstructive*/complications , Sleep Apnea, Obstructive*/diagnosis , Sleep Apnea, Obstructive*/physiopathology, Adult ; Cohort Studies ; Female ; Humans ; Hypoxia/blood ; Inflammation/blood ; Lymphocyte Count/methods ; Lymphocyte Count/statistics & numerical data ; Male ; Middle Aged ; Oxidative Stress ; Platelet Count/methods ; Platelet Count/statistics & numerical data ; Predictive Value of Tests ; Prognosis ; Severity of Illness Index ; Statistics as Topic ; Turkey
مستخلص: There is a strong relationship between obstructive sleep apnea syndrome (OSAS) and cardiovascular disease (CVD). Chronic intermittent hypoxia, inflammation, oxidative stress, and endothelial dysfunction may constitute etiologic mechanisms, linking OSAS to CVD. Inflammation play an important role in the development of CVD. Platelet-lymphocyte ratio (PLR) is a new biomarker showing inflammation. No previous study has ever investigated the association between PLR, CVD and OSAS severity in patients with OSAS. This study was designed to investigate the association between PLR and CVD in patients with OSAS, and relationship between severity of OSAS, polysomnographic parameters and PLR. This was a cohort study in which patients who had undergone a full night polysomnoraphy for diagnosis of OSA were recruited. Patients were divided according to their apnea-hypopnea index (AHI) scores into OSAS negative (Group 1: AHI < 5), mild (Group 2: AHI, 5-15), moderate (Group 3:AHI,15-30), and severe OSAS (Group 4: AHI > 30) groups. The presence of heart failure, coronary artery disease or arrhythmia was defined as CVD. A total of 424 patients were included in this study. There were 57, 93, 82, and 192 patients in Groups 1, 2, 3, and 4, respectively. PLR were significantly different between groups (Group 1: 87.38; Group 2: 95.07; Group 3: 97.01, Group 4: 126.9, P < 0.05). PLR were significantly correlated with AHI, oxygen desaturation index, average and minimum O2 saturation values (P < 0.05). Values of PLR were significantly higher in patients with CVD compared with those without. Multiple regression analysis demonstrated that PLR is an independent predictor of CVD. PLR cut-off value for demonstrating the presence of CVD is higher than 108.56. In the light oh findings, PLR is strongly associated with the severity of OSAS and cardiovascular disease in OSAS patients. PLR might be used as a biomarker to predict CVD in OSAS patients.
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تواريخ الأحداث: Date Created: 20140709 Date Completed: 20160323 Latest Revision: 20220331
رمز التحديث: 20240628
DOI: 10.1007/s11239-014-1103-4
PMID: 25002338
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-742X
DOI:10.1007/s11239-014-1103-4